| Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with (18)F-FEDAA1106. | |
| | |
MedLine Citation:
|
PMID: 18026949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k (3)/k (4)) of the peripheral benzodiazepine receptor using (18)F-FEDAA1106 and nonlinear least-square fitting. METHODS: Wavelet denoising within a three-dimensional discrete dual-tree complex wavelet transform was applied to simulate data and clinical dynamic positron emission tomography images of (18)F-FEDAA1106. To eliminate noise components in wavelet coefficients, real and imaginary coefficients for each subband were thresholded individually using NormalShrink. A simulated dynamic brain image of (18)F-FEDAA1106 was generated and Gaussian noise was added to mimic PET dynamic scan. The derived BP images were compared with true images using 156 rectangular regions of interest. Wavelet denoising was also applied to data derived from seven young normal volunteers. RESULTS: In the simulations, estimated BP by denoised image showed better correlation with the true BP values (Y = 0.83X + 0.94, r = 0.80), although no correlation was observed in the estimates between noise-added and true images (Y = 1.2X + 0.78, r = 0.49). For clinical data, there were visual improvements in the signal-to-noise ratio for estimated BP images. CONCLUSIONS: Wavelet denoising improved the bias and reduced the variation of pharmacokinetic parameters for BP. |
| | |
Authors:
|
Miho Shidahara; Yoko Ikoma; Chie Seki; Yota Fujimura; Mika Naganawa; Hiroshi Ito; Tetsuya Suhara; Iwao Kanno; Yuichi Kimura |
Related Documents
:
|
3872559 - Improved mr imaging of the orbit at 1.5 t with surface coils. 23130329 - Immediate hypersensitivity reactions to iv non-ionic iodinated contrast in computed tom... 1924789 - Rectal carcinoma: staging at mr imaging with endorectal surface coil. work in progress. 22693199 - Atypical rabies with mri findings: clue to the diagnosis. 22802869 - The value of magnetic resonance imaging in the early diagnosis of creutzfeldt-jakob dis... 11477679 - A low-cost system for monitoring skin conductance during functional mri. 23444259 - Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volume... 19470569 - Abnormally increased uptake of 18f-fdg in the forearm and hand following intra-arterial... 16944179 - Posttraumatic infarction in the territory supplied by the lateral lenticulostriate arte... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-20 |
Journal Detail:
|
Title: European journal of nuclear medicine and molecular imaging Volume: 35 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-21 Completed Date: 2008-08-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
|
Languages: eng Pagination: 416-23 Citation Subset: IM |
Affiliation:
|
Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, Japan. sidahara@nirs.go.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetamides
/
diagnostic use*,
pharmacokinetics* Adult Algorithms Artifacts Brain / metabolism*, radionuclide imaging* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Male Radiopharmaceuticals / diagnostic use, pharmacokinetics Receptors, GABA-A / metabolism* Reproducibility of Results Sensitivity and Specificity Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Acetamides; 0/N-(5-fluoro-2-phenoxyphenyl)-N-(2-fluoroethyl-5-methoxybenzyl)acetamide; 0/Radiopharmaceuticals; 0/Receptors, GABA-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Iliopsoas injury: an MRI study of patterns and prevalence correlated with clinical findings.
Next Document: Disseminated iodine-avid lung metastases in differentiated thyroid cancer: a challenge to 124I PET.