Document Detail


Wavelet cross-correlation to investigate regional variations in cerebral oxygenation in infants supported on extracorporeal membrane oxygenation.
MedLine Citation:
PMID:  22879034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracorporeal membrane oxygenation can potentially affect cerebral blood flow dynamics and consequently influence cerebral autoregulation. We applied wavelet cross-correlation (WCC) between multichannel cerebral oxyhemoglobin concentration (HbO(2)) and mean arterial pressure (MAP), to assess regional variations in cerebral autoregulation. Six infants on veno-arterial (VA) ECMO were studied during sequential changes in the ECMO flows. WCC between MAP and HbO(2) for each flow period and each channel was calculated within three different frequency (wavelet scale) bands centered around 0.1, 0.16, and 0.3 Hz chosen to represent low frequency oscillations, ventilation, and respiration rates, respectively. The group data showed a relationship between maximum WCC and ECMO flow. During changes in ECMO flow, statistically significant differences in maximum WCC were found between right and left hemispheres. WCC between HbO(2) and MAP provides a useful method to investigate the dynamics of cerebral autoregulation during ECMO. Manipulations of ECMO flows are associated with regional changes in cerebral autoregulation which may potentially have an important bearing on clinical outcome.
Authors:
Maria Papademetriou; Ilias Tachtsidis; Martin J Elliott; Aparna Hoskote; Clare E Elwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-12-11     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Arterial Pressure
Brain / blood supply*,  physiopathology
Cerebrovascular Circulation*
Extracorporeal Membrane Oxygenation / methods*
Homeostasis
Humans
Infant, Newborn
Monitoring, Physiologic*
Oxygen / metabolism*
Oxyhemoglobins / metabolism
Respiratory Insufficiency / prevention & control*
Wavelet Analysis*
Grant Support
ID/Acronym/Agency:
G0701458//Medical Research Council
Chemical
Reg. No./Substance:
0/Oxyhemoglobins; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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