Document Detail


Wavelength-Selective Uncaging of dA and dC Residues.
MedLine Citation:
PMID:  21341754     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Nitrodibenzofuran (NDBF) groups are used as photolabile "caging" groups to temporarily mask the Watson-Crick interaction of dA and dC residues. They show improved masking capabilities and are photodeprotected 12 times more efficiently than 1-(o-nitrophenyl)-ethyl (NPE) caging groups in these positions. Furthermore, NDBF groups can be removed wavelength-selectively in the presence of NPE groups. This will allow more complex (un)caging strategies of oligonucleotides - beyond the usual irreversible triggering.
Authors:
Florian Schäfer; Khashti Ballabh Joshi; Manuela A H Fichte; Timo Mack; Josef Wachtveitl; Alexander Heckel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-22
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cluster of Excellence Macromolecular Complexes, Goethe University of Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
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