Document Detail

Wavebreak formation during ventricular fibrillation in the isolated, regionally ischemic pig heart.
MedLine Citation:
PMID:  12600877     Owner:  NLM     Status:  MEDLINE    
Both fixed and dynamic heterogeneities were implicated in the mechanism of wavebreak (WB) generation during ventricular fibrillation (VF). However, their relative roles remain unclear. We hypothesized that during ischemic VF, the WBs are produced primarily because of a fixed heterogeneity; namely, the gradient of refractoriness across the ischemic border zone (BZ). Ischemia was induced in 15 isolated blood-perfused hearts by occluding the left anterior descending coronary artery. Simultaneous video imaging (approximately 32x32 mm2) of Di-4-ANEPPS fluorescence in the ischemic zone (IZ), the BZ, and the nonischemic zone (NIZ) was performed. Dominant-frequency maps were constructed to assess gradients of refractoriness during VF. We used singularity points analysis to quantify the incidence of WBs per square centimeter per second. During preischemic VF, the distribution of WBs was relatively uniform. Ischemia caused an increase of WBs in the BZ (from 6.2+/-2.8 to 10.8+/-4.0) and a decrease of WBs in the IZ (from 5.8+/-2.8 to 2.8+/-1.4), without a significant change in NIZ (from 6.4+/-2.3 to 4.1+/-1.7). This finding is fully consistent with the dominant-frequency distribution during ischemic VF: the average dominant frequency was significantly slower in IZ than in NIZ (7.8+/-0.7 versus 10.1+/-1.0 Hz), suggesting a large gradient in refractory periods across the BZ. We concluded that acute regional ischemia plays a dual role in the maintenance of VF, decreasing the incidence of WB in the IZ while increasing it in the BZ. This suggests a predominant role of fixed heterogeneities in the formation of WB during VF in acute regional ischemia.
Alexey V Zaitsev; Prabal K Guha; Farzad Sarmast; Arun Kolli; Omer Berenfeld; Arkady M Pertsov; Joris R de Groot; Ruben Coronel; José Jalife
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-02-13
Journal Detail:
Title:  Circulation research     Volume:  92     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-53     Citation Subset:  IM    
Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA.
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MeSH Terms
Acute Disease
Body Surface Potential Mapping
Heart / physiopathology
Myocardial Ischemia / physiopathology*
Organ Culture Techniques
Ventricular Fibrillation / physiopathology*
Grant Support

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