| Watershed infarcts in a multiple microembolic model of monkey. | |
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MedLine Citation:
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PMID: 21640789 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates. |
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Authors:
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Takakuni Maki; Hideaki Wakita; Mitsuhito Mase; Iori Itagaki; Naoyuki Saito; Fumiko Ono; Kayo Adachi; Hidefumi Ito; Ryosuke Takahashi; Masafumi Ihara; Hidekazu Tomimoto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-26 |
Journal Detail:
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Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Neurology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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