| Watershed infarctions are more prone than other cortical infarcts to cause early-onset seizures. | |
| | |
MedLine Citation:
|
PMID: 20937949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Early-onset seizures(ESs) have been reported in 2% to 6% of strokes. Most previous studies have been retrospective and did not systematically perform cerebral magnetic resonance imaging (MRI). OBJECTIVE: To determine the prevalence and determinants of ESs in a prospective cohort. DESIGN: Prospective cohort study. SETTING: Stroke unit in an academic hospital. PATIENTS: Six hundred sixty-one consecutive individuals admitted to our stroke unit during an 18-month period for suspected stroke. MAIN OUTCOME MEASURES: Initial investigations systematically included cerebral MRI. Among patients with MRI-confirmed cerebral infarction, individuals with ES, defined as occurring within 14 days of stroke, were identified. RESULTS: Three hundred twenty-eight patients had MRI-confirmed cerebral infarcts and 178 had cortical involvement. The ESs, all initially partial seizures, occurred in 14 patients (4.3%) and at stroke onset in 5 patients. The ESs occurred exclusively in patients with cortical involvement (P <.001). With infarcts involving the cerebral cortex, there was a higher risk of ESs in watershed infarctions than in territorial strokes (6 of 26 [23.1%] vs 8 of 152 [5.3%], P = .007). Logistic regression analysis showed an almost 4-fold increased risk of ES in patients with watershed infarctions compared with other cortical infarcts (odds ratio, 4.7; 95% confidence interval, 1.5- 15.4; P = .01). Age, sex, diabetes mellitus, hypertension, smoking, National Institutes of Health Stroke Scale score, and cardioembolic origin were not significant risk factors for ES. CONCLUSIONS: The cortical hemispheric location of ischemic strokes is associated with a higher risk of ES. Among these patients, the watershed mechanism is a strong and independent determinant of stroke-related ES. |
| | |
Authors:
|
Christian Denier; Pascal Masnou; Yacouba Mapoure; Raphaelle Souillard-Scemama; Thierry Guedj; Marie Théaudin; Ombeline Fagniez; Claire Join-Lambert; Pierre Lozeron; Béatrice Ducot; Denis Ducreux; David Adams |
Related Documents
:
|
8809529 - Potential cardioembolic sources in an elderly population without stroke. a transthoraci... 17108679 - Mannheim carotid intima-media thickness consensus (2004-2006). an update on behalf of t... 19137129 - Pathophysiology and therapeutic strategies in the management of stroke: an update. 12499489 - Strokes restricted to the insular cortex. 12604269 - The influence of diabetes mellitus and hyperglycaemia on stroke incidence and outcome. 11810009 - Increased serum levels of endogenous protectant secretory leukocyte protease inhibitor ... 17347039 - Clinical diagnosis of left ventricular dilatation and dysfunction in the age of technol... 22158969 - Myocardial atgl overexpression decreases the reliance on fatty acid oxidation and prote... 6807569 - Two-dimensional echocardiography in experimental coronary stenosis. ii. relationship be... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of neurology Volume: 67 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-12 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 1219-23 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Centre Hospitalo-Universitaire de Bicêtre, 94275 Le Kremlin-Bicêtre Cedex, France. christian.denier@bct.aphp.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Cerebral Infarction / complications* Cohort Studies Female Humans Magnetic Resonance Imaging / methods Male Middle Aged Retrospective Studies Risk Factors Seizures / etiology* Stroke / complications*, pathology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ACCESS: Acute Cerebrovascular Care in Emergency Stroke Systems.
Next Document: Retinopathy and Lobar Intracerebral Hemorrhage: Insights Into Pathogenesis.