Document Detail

Water uptake in stimulated cat skeletal muscle.
MedLine Citation:
PMID:  8476122     Owner:  NLM     Status:  MEDLINE    
Isolated vasodilated cat hindlimb skeletal muscles were perfused at constant flow and stimulated at 4 Hz for 2-4 min in three studies. Water uptake rates were measured gravimetrically or calculated from venous protein concentration changes. Venous plasma sodium, potassium, chloride, and osmolality were also measured. Maximum water uptake rates averaged 1.8 +/- 0.2 (SE) ml.min-1 x 100 g-1, reaching twice that in some experiments. Water uptake continued after stimulation had ceased. Constant-flow perfusion maintained a constant capillary pressure that was corroborated by measurements of arterial and venous perfusate pressures. Water uptake rate was not influenced by hematocrit but was highly correlated with plasma flow rate. The evidence strongly suggests that small-molecule osmotic pressure was the primary pressure causing the transcapillary water flux. Venous plasma sodium and chloride concentrations increased almost as much as protein (108 and 87% of the protein increase, respectively), as would be expected when water fluxes are driven by small-molecule osmotic pressure. Peak potassium efflux averaged 36 +/- 3 mu eq.min-1 x 100 g-1, but potassium did not contribute significantly to the osmotic gradient.
P D Watson; R P Garner; D S Ward
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R790-6     Citation Subset:  IM    
Department of Physiology, University of South Carolina, Columbia 29208.
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MeSH Terms
Biological Transport / physiology
Body Water*
Chlorides / blood
Electric Stimulation
Extracellular Space / metabolism
Muscles / blood supply,  metabolism,  physiology*
Osmolar Concentration
Potassium / blood
Regional Blood Flow / physiology
Sodium / blood
Water-Electrolyte Balance
Grant Support
Reg. No./Substance:
0/Chlorides; 7440-09-7/Potassium; 7440-23-5/Sodium

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