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Water signal attenuation by D(2) O infusion as a novel contrast mechanism for (1) H perfusion MRI.
MedLine Citation:
PMID:  23355425     Owner:  NLM     Status:  Publisher    
Deuterium oxide (D(2) O), which is commercially available and nonradioactive, was proposed as a perfusion tracer before the clinical usage of conventional gadolinium-based MRI contrast agents. However, the sensitivity of direct deuterium detection is the major challenge for its application. In this study, we propose a contrast-enhanced strategy to indirectly trace administered D(2) O by monitoring the signal attenuation of (1) H MRI. Experiments on D(2) O concentration phantoms and in vivo rat brains were conducted to prove the concept of the proposed contrast mechanism. An average maximum signal drop ratio of 5.25 ± 0.91% was detected on (1) H MR images of rat brains with 2 mL of D(2) O administered per 100 g of body weight. As a diffusible tracer for perfusion, D(2) O infusion is a practicable method for the assessment of tissue perfusion and has the potential to provide different information from gadolinium-based contrast agents, which have limited permeability for blood vessels. Furthermore, the observed negative relaxivities of D(2) O reveal the (1) H-D exchange effect. Therefore, applications of perfusion MRI with D(2) O as a contrast agent are worthy of further investigation. Copyright © 2013 John Wiley & Sons, Ltd.
Fu-Nien Wang; Shin-Lei Peng; Chin-Tien Lu; Hsu-Hsia Peng; Tzu-Chen Yeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  NMR in biomedicine     Volume:  -     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Department of Biomedical Engineering and Environmental Sciences, College of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan.
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