| Water signal attenuation by D(2) O infusion as a novel contrast mechanism for (1) H perfusion MRI. | |
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MedLine Citation:
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PMID: 23355425 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Deuterium oxide (D(2) O), which is commercially available and nonradioactive, was proposed as a perfusion tracer before the clinical usage of conventional gadolinium-based MRI contrast agents. However, the sensitivity of direct deuterium detection is the major challenge for its application. In this study, we propose a contrast-enhanced strategy to indirectly trace administered D(2) O by monitoring the signal attenuation of (1) H MRI. Experiments on D(2) O concentration phantoms and in vivo rat brains were conducted to prove the concept of the proposed contrast mechanism. An average maximum signal drop ratio of 5.25 ± 0.91% was detected on (1) H MR images of rat brains with 2 mL of D(2) O administered per 100 g of body weight. As a diffusible tracer for perfusion, D(2) O infusion is a practicable method for the assessment of tissue perfusion and has the potential to provide different information from gadolinium-based contrast agents, which have limited permeability for blood vessels. Furthermore, the observed negative relaxivities of D(2) O reveal the (1) H-D exchange effect. Therefore, applications of perfusion MRI with D(2) O as a contrast agent are worthy of further investigation. Copyright © 2013 John Wiley & Sons, Ltd. |
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Authors:
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Fu-Nien Wang; Shin-Lei Peng; Chin-Tien Lu; Hsu-Hsia Peng; Tzu-Chen Yeh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Biomedical Engineering and Environmental Sciences, College of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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