Document Detail

Water retention and drainage in different brands of microcrystalline cellulose: effect of measuring conditions.
MedLine Citation:
PMID:  16527466     Owner:  NLM     Status:  MEDLINE    
Interaction between water and microcrystalline cellulose (MCC) measured as retention and cumulative drainage of water (WR% and CDW%) is investigated for unmilled and micronized standard (Avicel and Emcocel) and silicified (Prosolv) MCC brands. A centrifuge method was applied with increasing duration and different porosity and thickness of cylindrical powder beds (specimens), in order to establish optimal determination conditions and quantify alterations in interaction between water and different MCC brands. Also, changes of specimen thickness due to presence of water (swelling) were followed. It was found that the effect of specimen porosity and thickness on water drainage (CDW%) appears to be opposite to that on water retention (WR%), while two patterns of WR% and CDW% change with specimen porosity and thickness can be distinguished depending on the centrifugation time. Also, WR% and CDW% are affected by the MCC brand and the micronization. Unmilled silicified MCC brand (Prosolv) shows significantly lower retention and higher drainage of water compared to standard unmilled brands (Avicel and Emcocel), while differences between the unmilled standard Avicel and Emcocel brands are not easily distinguished. Micronization, in general, increases greatly the WR% and decreases CDW% for all the tested MCC brands, and enhances their differences even between Avicel and Emcocel. Swelling of specimen due to presence of water was observed, which was significantly reduced with the micronization, the specimen porosity, and centrifugation as well, but showed slight variation between the different MCC brands. Values of specimen porosity between 60% and 70%, thickness/diameter ratio between 0.75 and 1.0, and centrifugation time between 5 and 20 min provide optimal measuring settings for comparison of MCC brands.
Ioannis Nikolakakis; Konstantina Tsarvouli; Stavros Malamataris
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Publication Detail:
Type:  Journal Article     Date:  2006-03-09
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  63     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-05-30     Completed Date:  2006-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  278-87     Citation Subset:  IM    
Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Cellulose / chemistry*
Chemistry, Pharmaceutical
Powders / chemistry
Silicones / chemistry
Water / chemistry
Reg. No./Substance:
0/Powders; 0/Silicones; 0/microcrystalline cellulose; 7732-18-5/Water; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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