| Water losses induced by heat exposure and the kinin system in the rat. | |
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MedLine Citation:
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PMID: 7691218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal Wistar rats, normal and kininogen-deficient Brown Norway rats were kept at ambiant temperatures of 26 degrees C, 36 degrees C or 40 degrees C for 3 to 5 hours. Their colonic temperatures and body weights were measured. At 26 degrees C, the changes in these parameters were similar in the three strains. At 36 degrees C, body weight loss was increased more in normal rats than in kininogen-deficient rats. At 40 degrees C, body temperature increased more quickly and body weight loss was less enhanced in kininogen-deficient rats than in normal rats. The water content of muscles was less reduced in kininogen-deficient rats than in normal rats. HOE 140, a bradykinin antagonist, reduced the weight loss of Wistar rats kept at 36 degrees C and 40 degrees C. Atropine or removal of submaxillary glands increased colonic temperature and reduced the weight loss of Wistar rats at 36 degrees C and 40 degrees C. HOE 140 did not modify the reduction of weight loss induced by atropine but increased colonic temperatures and decreased thermal tolerance of atropinized Wistar rats at 36 degrees C. These results indicate that the kallikrein-kinin system plays a role in salivary secretion and in heat exchange during a heat exposure. |
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Authors:
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J Damas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives internationales de physiologie, de biochimie et de biophysique Volume: 101 ISSN: 0778-3124 ISO Abbreviation: Arch Int Physiol Biochim Biophys Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-11-15 Completed Date: 1993-11-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9111069 Medline TA: Arch Int Physiol Biochim Biophys Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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Department of Human Physiology, University of Liège, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects, physiology Body Water / metabolism* Bradykinin / analogs & derivatives, antagonists & inhibitors, pharmacology Hot Temperature* Kallikreins / physiology* Kininogens / deficiency* Kinins / antagonists & inhibitors, physiology* Male Rats Rats, Inbred BN Rats, Wistar Reference Values Salivary Glands / secretion* Weight Loss / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Kininogens; 0/Kinins; 130308-48-4/icatibant; 58-82-2/Bradykinin; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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