Document Detail


Water and electrolyte changes in skeletal and cardiac muscles of rats during prolonged hypokinesia.
MedLine Citation:
PMID:  17022373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to show that hypokinesia (diminished movement) could affect differently water and electrolyte content in muscles having minimum differences in their function and morphology. To this end, we studied water and electrolyte content in skeletal and cardiac muscles, fluid excretion, electrolyte absorption, and electrolyte levels in plasma, urine and feces of rats during prolonged hypokinesia (HK). Studies were conducted on one-hundred-twenty-six 13-weeks old male Wister rats during a pre-hypokinetic period and a hypokinesia period. Animals were equally divided into two groups: vivarium control rats (VCR) and hypokinetic rats (HKR). Hypokinetic animals were kept in small individual cages which restricted their movements in all directions without hindering food and water intake. Control rats were housed in individual cages under vivarium control conditions. Sodium (Na+) and potassium (K+) absorption, electrolyte and water content in cardiac muscles (right and left ventricle), thigh extensor (quadriceps femoris muscle) and long muscle of the back (biceps femoris muscle), urine volume, and electrolyte levels in plasma and urine and feces did not change in VCR when compared to their pre-hypokinetic levels. The absorption of Na+ and K+, water and electrolyte content in cardiac and skeletal muscles decreased significantly, while urine volume, plasma electrolyte levels and urine and fecal electrolyte excretion increased significantly in HKR compared with their pre-HK values and with their respective vivarium control (VCR). Water and electrolyte content decreased more significantly in skeletal than in cardiac muscles. Water and electrolyte levels decreased more in the thigh extensor and in the right ventricle than in the long muscle of the back, the left ventricle or the septum. Muscles suffering from higher water and electrolyte loss against the background of lower water and electrolyte content show lower water and electrolyte deposition. Lower electrolyte and water content in skeletal than in cardiac muscle shows that water and electrolyte content decreases more in skeletal than cardiac muscles. Skeletal muscle showed lower water and electrolyte content than cardiac muscle indicating that the risk for decreased muscle water and electrolyte content is inversely related to the muscle function and morphology, i.e., the more weight-bearing supporting function and morphology muscles have, the higher the risk for lower muscle water and electrolyte content. It was concluded that the greater muscle function and morphology, the lower electrolyte and water deposition, the higher water and electrolyte losses, and the lower water and electrolyte content.
Authors:
Yan G Zorbas; Kostas K Kakuris; Eugenios A Neofitos; Nikolaos I Afoninos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological chemistry and physics and medical NMR     Volume:  37     ISSN:  0748-6642     ISO Abbreviation:  Physiol Chem Phys Med NMR     Publication Date:  2005  
Date Detail:
Created Date:  2006-10-06     Completed Date:  2006-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502230     Medline TA:  Physiol Chem Phys Med NMR     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-40     Citation Subset:  IM    
Affiliation:
Higher Institute of Biochemistry, Gomel, Belarus.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electrolytes / blood,  metabolism*,  urine
Feces / chemistry
Hypokinesia / metabolism*,  pathology
Male
Muscle, Skeletal / metabolism*,  pathology
Myocardium / metabolism*,  pathology
Potassium / metabolism
Rats
Rats, Wistar
Sodium / metabolism
Water / analysis*
Water-Electrolyte Balance*
Chemical
Reg. No./Substance:
0/Electrolytes; 7440-09-7/Potassium; 7440-23-5/Sodium; 7732-18-5/Water

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