Document Detail

Water as it applies to the function of enzymes.
MedLine Citation:
PMID:  11952237     Owner:  NLM     Status:  MEDLINE    
Escherichia coli and Saccharomyces cerevisiae can metabolize, grow, and divide over osmotic pressures ranging from 0.24 atm to about 100 atm [Record, T. M. et al. (1999). Trends Biochem. Sci. 23,143-148,190-194; Wood, J. M. (1999). Microbiol. Mol. Bio. Rev. 63, 230-262; Marachal, P. A., and Gervais, P. (1994). Appl. Microbiol. Biotechnol. 42, 617-622]. At the higher end of the range, they perform their functions with difficulty, but they can survive. Over the full span of pressures, the activity of water goes from 0.9998 to 0.93. Neither of the authors can survive at anything like these extremes; some of their enzymes and enzymatic complexes would "fall apart," would either cease to function or would denature. We would very much like to know just how the two microbes manage.
J A Kornblatt; M J Kornblatt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International review of cytology     Volume:  215     ISSN:  0074-7696     ISO Abbreviation:  Int. Rev. Cytol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-15     Completed Date:  2002-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985180R     Medline TA:  Int Rev Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-73     Citation Subset:  IM    
Enzyme Research Group, Department of Biology, Concordia University, Montreal, Quebec, Canada.
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MeSH Terms
Binding Sites / physiology
Body Water / chemistry*
Cytochrome c Group / chemistry
Enzymes / chemistry*
Eukaryotic Cells / enzymology*
Molecular Structure
Osmotic Pressure
Reg. No./Substance:
0/Cytochrome c Group; 0/Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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