Document Detail

Washout and redistribution between immediate and two-hour myocardial images using technetium-99m sestamibi.
MedLine Citation:
PMID:  7698155     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess whether a clinically relevant change in myocardial sestamibi activity could be documented within the first 120 min following injection (p.i.). In 17 patients planar anterior imaging of the heart was performed 5 min and 120 min p.i. During this time interval, mean decay-corrected myocardial activity declined to 77.9% +/- 9.7% after stress and to 85.7% +/- 7.9% after injection at rest (P < 0.05). In 19 patients with angiographically documented coronary artery disease, single-photon emission tomography was performed 5 min and 120 min after injection at maximum stress. For analysis, sestamibi activity was scored semiquantitatively in six left ventricular segments. Furthermore, sestamibi uptake was assessed quantitatively using a circumferential profile method. In 35 of 114 segments the score improved within 120 min p.i. (early fill-in); in these segments relative sestamibi activity rose from 69.9% +/- 22.5% to 74.5% +/- 20.8% (P < 0.01). In five patients this early fill-in was the only sign of exercise-induced hypoperfusion. In 7 of 114 segments the score deteriorated 120 min p.i. (early tracer washout); in these segments relative sestamibi activity declined from 85.6% +/- 9.9% to 80.1% +/- 10.7% (P < 0.02). In three of four patients with early tracer washout the corresponding coronary artery was significantly narrowed. In conclusion, a global myocardial sestamibi washout was registered within the first 120 min after injection. A fill-in of initial defects as well as an early tracer loss could be detected in a relevant number of patients with chronic coronary artery disease during the first 2 h p.i.(ABSTRACT TRUNCATED AT 250 WORDS)
W S Richter; M Cordes; D Calder; H Eichstaedt; R Felix
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  22     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Germany.
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MeSH Terms
Coronary Circulation / physiology
Coronary Disease / radionuclide imaging*
Exercise Test
Heart / radionuclide imaging*
Middle Aged
Technetium Tc 99m Sestamibi / diagnostic use*
Time Factors
Tomography, Emission-Computed, Single-Photon* / methods
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi

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