Document Detail


Washout of the pig liver with Haemaccel after hypothermic preservation.
MedLine Citation:
PMID:  2379995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In hepatic preservation by simple perfusion and hypothermic storage, a portal and hepatic washout before revascularization would avoid receptor hyperkaliema. In this report we study the effectiveness of this washout with Haemaccel at room temperature. Large-White pigs were used and eight livers were perfused "in situ" via the portal wein with Hartmann's solution containing 10,000 IU of heparin at 4 degrees C, and afterwards, via portal and arterial routes with C2 solution at 4 degrees C. After a cold ischemia time of less than 31/2 hours a liver washout via the portal vein and hepatic artery with Haemaccel before portal revascularization was done. The high concentrations of glucose, K+, GOT, GPT and LDH in the effluents obtained during the washout are attributed to Haemaccel hyperosmolarity. A portal and arterial hepatic washout associated with free drainage of the first 50-100 ml of portal venous blood after hepatic portal revascularization through the infrahepatic inferior vena cava (IH-IVC), prevents hyperkaliemia from occurring after a portal and arterial revascularization in the orthotopic liver transplant (OLT) in pigs.
Authors:
J Arias; M A Aller; L Lorente; J C Rodriguez; X Fernández; D Brandau; H Durán
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  75     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    1990 Apr-Jun
Date Detail:
Created Date:  1990-09-07     Completed Date:  1990-09-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Affiliation:
I Cátedra de Patología Quirúrgica, Hospital Universitario San Carlos, Universidad Complutense de Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cold Temperature*
Hypertonic Solutions / administration & dosage
Isotonic Solutions / administration & dosage
Liver / blood supply*
Liver Transplantation*
Organ Preservation / methods*
Osmolar Concentration
Perfusion
Polygeline / administration & dosage*
Polymers / administration & dosage*
Swine
Chemical
Reg. No./Substance:
0/Collins' solution; 0/Hypertonic Solutions; 0/Isotonic Solutions; 0/Polymers; 8022-63-7/Ringer's lactate; 8026-10-6/Ringer's solution; 9015-56-9/Polygeline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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