Document Detail

Warthin's tumour associated with autoimmune diseases and tobacco use.
MedLine Citation:
PMID:  9288224     Owner:  NLM     Status:  MEDLINE    
To better clarify the possible role of immune mechanisms in the pathogenesis of Warthin's tumour (WT), we performed a retrospective study of patients with WT surgically treated at the Institute of Otolaryngology Head and Neck Surgery, University of Florence, during a 25-year period; looking for a possible association with autoimmune pathologies. The retrospective analysis of clinical records of 140 WT patients compared with those of 380 patients with pleomorphic adenoma revealed a higher incidence of autoimmune disorders, particularly organ-specific disease (i.e. insulin-dependent diabetes mellitus, Hashimoto's thyroiditis, autoimmune hyperthyroidism and hypothyroidism) in WT patients than in pleomorphic adenoma (PA) patients (23% vs 3%; R.R.: 8.69; p < 0.0001). Moreover, we demonstrate a positive smoking history in 87% of WT patients compared to only 38% of PA subjects (p < 0.001). Because of the well-known possible association among multiple immune disorders, our data support the hypothesis of an immune pathogenesis of WT and also suggest the possible role of tobacco smoke in facilitating such immune reactions responsible for the lympho-epithelial coexistence of WT.
O Gallo; C Bocciolini
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  117     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  623-7     Citation Subset:  IM    
Department of Head and Neck Surgery, University of Florence, Italy.
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MeSH Terms
Adenolymphoma / complications*,  epidemiology
Autoimmune Diseases / complications*,  epidemiology
Middle Aged
Parotid Neoplasms / complications*,  epidemiology
Retrospective Studies
Tobacco Use Disorder / complications*

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