| "Warm-up" phenomenon detected by electrocardiographic ambulatory monitoring in adult and older patients. | |
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MedLine Citation:
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PMID: 10484256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Inducing tolerance to myocardial ischemia by repeated brief episodes of ischemia has been called "ischemic preconditioning." "Warm-up" phenomenon refers to patients with coronary heart disease improving performance after a first exertion and may represent a clinical counterpart to ischemic preconditioning. The goal of this study was to assess whether the severity of myocardial ischemia would be attenuated by two repeated walking-induced ischemic episodes in adult and older patients. SUBJECTS: Thirty-eight adults (51 +/- 5 years) and 39 older patients (76 +/- 4 years) with stable angina and angiographic evidence of coronary stenosis. MEASUREMENTS: Holter monitoring was performed in adult and older patients walking on two consecutive occasions, with a 5-minute rest between walks, a distance known to have previously caused myocardial ischemia. RESULTS: Computer-assisted analysis recorded by ambulatory Holter monitoring revealed that the mean maximal ST-segment depression (P < .001) and ischemia duration decreased (P < .001), whereas the ischemic threshold increased (P < .001), from the first to the second walk in the adult but not in the older group. CONCLUSIONS: Myocardial ischemia is attenuated and ischemic threshold is increased between two brief ischemic episodes in adult but not in older patients. These results indicate that the "warm-up" phenomenon, involved in increasing myocardial ischemic tolerance, is absent in the aging heart. |
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Authors:
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C Napoli; A Liguori; F Cacciatore; F Rengo; G Ambrosio; P Abete |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 47 ISSN: 0002-8614 ISO Abbreviation: J Am Geriatr Soc Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-28 Completed Date: 1999-09-28 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1114-7 Citation Subset: IM |
Affiliation:
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Dipartimento di Medicina Clinica e Sperimentale, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology* Analysis of Variance Angina Pectoris / physiopathology* Chronic Disease Electrocardiography, Ambulatory / methods Female Humans Ischemic Preconditioning, Myocardial / methods* Male Middle Aged Signal Processing, Computer-Assisted Walking / physiology* |
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