| Warfarin and intracranial haemorrhage. | |
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MedLine Citation:
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PMID: 18583002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUMMARY: Spontaneous intracerebral haemorrhage is one of the most feared complications of long-term anticoagulation. Warfarin therapy not only increases the likelihood of suffering an intracranial haemorrhage, but also increases the mortality associated with it. This review aims to examine the incidence, pathogenesis, and outcome following a warfarin associated intracranial haemorrhage. It also evaluates the available evidence regarding optimal management of these patients, including timing and strategies for reversal of the coagulopathy, the role of neurocritical care and surgery, and indications for re-anticoagulation once the acute phase has past. The specific management of patients with prosthetic heart valves is also discussed. A summary of current societal guidelines is also included, as are some key practice points. |
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Authors:
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Rebecca Appelboam; Elfyn O Thomas |
Publication Detail:
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Type: Journal Article; Review Date: 2008-06-25 |
Journal Detail:
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Title: Blood reviews Volume: 23 ISSN: 1532-1681 ISO Abbreviation: Blood Rev. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708558 Medline TA: Blood Rev Country: England |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Anaesthesia and Intensive Care Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter, Devon, UK. appelboamr@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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adverse effects* Blood Coagulation Factors / therapeutic use Factor VIIa / therapeutic use Humans Incidence Intracranial Hemorrhages / etiology*, mortality, physiopathology, therapy* Recombinant Proteins / therapeutic use Vitamin K / therapeutic use Warfarin / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Blood Coagulation Factors; 0/Recombinant Proteins; 0/recombinant FVIIa; 12001-79-5/Vitamin K; 37224-63-8/prothrombin complex concentrates; 81-81-2/Warfarin; EC 3.4.21.21/Factor VIIa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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