Document Detail

Warfarin and intracranial haemorrhage.
MedLine Citation:
PMID:  18583002     Owner:  NLM     Status:  MEDLINE    
Spontaneous intracerebral haemorrhage is one of the most feared complications of long-term anticoagulation. Warfarin therapy not only increases the likelihood of suffering an intracranial haemorrhage, but also increases the mortality associated with it. This review aims to examine the incidence, pathogenesis, and outcome following a warfarin associated intracranial haemorrhage. It also evaluates the available evidence regarding optimal management of these patients, including timing and strategies for reversal of the coagulopathy, the role of neurocritical care and surgery, and indications for re-anticoagulation once the acute phase has past. The specific management of patients with prosthetic heart valves is also discussed. A summary of current societal guidelines is also included, as are some key practice points.
Rebecca Appelboam; Elfyn O Thomas
Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-25
Journal Detail:
Title:  Blood reviews     Volume:  23     ISSN:  1532-1681     ISO Abbreviation:  Blood Rev.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-10     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Anaesthesia and Intensive Care Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter, Devon, UK.
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MeSH Terms
Anticoagulants / adverse effects*
Blood Coagulation Factors / therapeutic use
Factor VIIa / therapeutic use
Intracranial Hemorrhages / etiology*,  mortality,  physiopathology,  therapy*
Recombinant Proteins / therapeutic use
Vitamin K / therapeutic use
Warfarin / adverse effects*
Reg. No./Substance:
0/Anticoagulants; 0/Blood Coagulation Factors; 0/Recombinant Proteins; 0/recombinant FVIIa; 12001-79-5/Vitamin K; 37224-63-8/prothrombin complex concentrates; 81-81-2/Warfarin; EC VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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