Document Detail


Warfarin-induced skin necrosis.
MedLine Citation:
PMID:  10715767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skin necrosis is a rare but serious side-effect of treatment with warfarin. At particular risk are those with various thrombophilic abnormalities, especially when warfarinization is undertaken rapidly with large loading doses of warfarin. With the increasing number of patients anticoagulated as out-patients for thromboprophylaxis, we are concerned that the incidence of skin necrosis may increase. If skin necrosis does occur, prompt remedial action may be of benefit in preventing permanent tissue damage.
Authors:
A J Stewart; I D Penman; M K Cook; C A Ludlam
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  75     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-04-13     Completed Date:  2000-04-13     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-5     Citation Subset:  IM    
Affiliation:
Department of Haematology, St John's Hospital at Howden, Livingston, West Lothian, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / adverse effects*
Drug Eruptions / etiology*,  pathology
Female
Humans
Necrosis
Skin / drug effects,  pathology*
Warfarin / adverse effects*
Chemical
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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