Document Detail


Warfarin embryopathy: fetal manifestations.
MedLine Citation:
PMID:  20922410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the period 1991-2007, autopsy was undertaken in 13 fetuses with warfarin embryopathy. Pregnancy data and radiographic babygrams were available in each instance. Gestational age ranged from 17 to 37 weeks. Eleven of the fetuses had the characteristic nasal hypoplasia, but only three had radiological epiphyseal stippling. Cerebral hemorrhage was a major feature of autopsy in 8 of the fetuses, and it is evident that bleeding is a significant factor in the pathogenesis of warfarin embryopathy. A wide variety of additional visceral manifestations which were observed at autopsy have been tabulated. There was no obvious correlation between maternal or gestational age and the presence and severity of any specific embryopathic feature. No information was available concerning the dose and timing of warfarin administration in this series.
Authors:
Helen Wainwright; Peter Beighton
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-05
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  457     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  IM    
Affiliation:
Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / diagnosis,  pathology*
Adolescent
Adult
Anticoagulants / adverse effects*,  pharmacology,  therapeutic use
Autopsy
Cerebral Hemorrhage / chemically induced,  pathology
Chondrodysplasia Punctata / chemically induced,  pathology
Female
Fetal Development / drug effects
Heart Valve Diseases / drug therapy
Humans
Hyperplasia / chemically induced,  pathology
Nose / abnormalities,  drug effects,  pathology*
Pregnancy
Retrospective Studies
Warfarin / adverse effects*,  pharmacology,  therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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