| Warfarin embryopathy: fetal manifestations. | |
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MedLine Citation:
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PMID: 20922410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the period 1991-2007, autopsy was undertaken in 13 fetuses with warfarin embryopathy. Pregnancy data and radiographic babygrams were available in each instance. Gestational age ranged from 17 to 37 weeks. Eleven of the fetuses had the characteristic nasal hypoplasia, but only three had radiological epiphyseal stippling. Cerebral hemorrhage was a major feature of autopsy in 8 of the fetuses, and it is evident that bleeding is a significant factor in the pathogenesis of warfarin embryopathy. A wide variety of additional visceral manifestations which were observed at autopsy have been tabulated. There was no obvious correlation between maternal or gestational age and the presence and severity of any specific embryopathic feature. No information was available concerning the dose and timing of warfarin administration in this series. |
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Authors:
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Helen Wainwright; Peter Beighton |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-05 |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 457 ISSN: 1432-2307 ISO Abbreviation: Virchows Arch. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 735-9 Citation Subset: IM |
Affiliation:
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Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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diagnosis,
pathology* Adolescent Adult Anticoagulants / adverse effects*, pharmacology, therapeutic use Autopsy Cerebral Hemorrhage / chemically induced, pathology Chondrodysplasia Punctata / chemically induced, pathology Female Fetal Development / drug effects Heart Valve Diseases / drug therapy Humans Hyperplasia / chemically induced, pathology Nose / abnormalities, drug effects, pathology* Pregnancy Retrospective Studies Warfarin / adverse effects*, pharmacology, therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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