| Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer. | |
| | |
MedLine Citation:
|
PMID: 17574287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ocular gene therapy may offer new hope for severe eye diseases. Many of these ocular diseases are due to a gene defect in the retina, a multi-layered sensory tissue that lines the back of the eye. However, it is well known that the blood-retina barrier and sclera prevent hydrophilic and high molecular weight drugs to reach the retina after systemic or topical application. Therefore, intravitreal injection of non-viral nucleic acid nanoparticles has been considered as a safe and promising approach in ocular gene transfer. However, after intravitreal injection the non-viral nucleic acid nanoparticles should be stable and mobile in the vitreous. In this overview we focus on the behavior of non-viral nucleic acid nanoparticles (lipoplexes) in vitreous and on PEGylation strategies that improve their behavior in vitreous, but that do not affect their transfection capacity. |
| | |
Authors:
|
Niek N Sanders; Liesbeth Peeters; Ine Lentacker; Joseph Demeester; Stefaan C De Smedt |
Related Documents
:
|
11537767 - Self-instructed condensation of amino acids into polymers. 17150517 - Synergistic stabilization of triplex by combination of comb-type cationic copolymer and... 435077 - Alkylation of rna by vinyl bromide metabolites in vitro and in vivo. 16852867 - Light-induced structural transformation in self-assembled monolayer of 4-(amyloxy)cinna... 4701547 - Activation of branched and other long-chain fatty acids by rat liver microsomes. 20814967 - Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhpth(1-34)] in ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-05-13 |
Journal Detail:
|
Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 122 ISSN: 1873-4995 ISO Abbreviation: J Control Release Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-21 Completed Date: 2007-11-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 226-35 Citation Subset: IM |
Affiliation:
|
Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium. Niek.Sanders@UGent.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cattle Drug Carriers* / administration & dosage, adverse effects, chemistry Drug Stability Epithelial Cells / drug effects, metabolism Eye Diseases / therapy Gene Therapy / methods Gene Transfer Techniques* Humans Liposomes Luciferases, Firefly / genetics Microbubbles Nanoparticles* / administration & dosage, adverse effects, chemistry Nucleic Acids / administration & dosage*, genetics Pigment Epithelium of Eye / cytology Polyethylene Glycols* / administration & dosage, adverse effects, chemistry Transfection Ultrasonics Vitreous Body / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Drug Carriers; 0/Liposomes; 0/Nucleic Acids; 0/Polyethylene Glycols; EC 1.13.12.7/Luciferases, Firefly |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV/AIDS: in search of an animal model.
Next Document: Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpres...