Document Detail


Wall-to-lumen ratio of retinal arterioles is related with urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine.
MedLine Citation:
PMID:  19625969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We hypothesized that wall-to-lumen ratio (WLR) of retinal arterioles might serve as an in-vivo parameter of vascular damage. To test this hypothesis we examined whether WLR of retinal arterioles is related with increased urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine (L-NMMA).
METHODS: Thirty-nine never-treated male patients aged 18-65 years with a body mass index at least 25 kg/m(2) and without diabetes mellitus or secondary or stage 3 arterial hypertension were examined. WLR of retinal arterioles was assessed using scanning laser Doppler flowmetry. Urinary albumin-to-creatinine ratio (UACR) was measured from first morning spot urine. Vascular reactivity was measured by the change of aortic augmentation index (aAIx) to infusion of L-NMMA.
RESULTS: UACR was related with WLR of retinal arterioles (r = 0.352, P = 0.032). In response to L-NMMA infusion aAIx increased (from 10.7 +/- 11 to 19.7 +/- 11%, P < 0.001). The change of aAIx to L-NMMA infusion was inversely related with WLR of retinal arterioles (r = -0.462, P = 0.003) even after adjustment for changes of hemodynamic parameters to L-NMMA infusion (partial r = -0.475, P = 0.005). The relationships of UACR and the change of aAIx to L-NMMA infusion with WLR of retinal arterioles were found to be independently of other cardiovascular risk factors (ss = 0.386, P = 0.006; ss = -0.369, P = 0.004, respectively) in multiple regression analyses with separate models for both parameters.
CONCLUSION: Increased WLR of retinal arterioles may thus serve as an in-vivo marker of vascular damage.
Authors:
Martin Ritt; Joanna M Harazny; Christian Ott; Markus P Schneider; Markus P Schlaich; Georg Michelson; Roland E Schmieder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  27     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2201-8     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Albuminuria*
Arterioles / anatomy & histology*
Enzyme Inhibitors / pharmacology*
Humans
Laser-Doppler Flowmetry
Male
Middle Aged
Nitric Oxide Synthase / antagonists & inhibitors*
Retinal Vessels / anatomy & histology*
Tunica Intima / anatomy & histology*
Young Adult
omega-N-Methylarginine / pharmacology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 17035-90-4/omega-N-Methylarginine; EC 1.14.13.39/Nitric Oxide Synthase
Comments/Corrections
Comment In:
J Hypertens. 2009 Nov;27(11):2162-4   [PMID:  20724870 ]

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