| Wall thickening at rest and contractile reserve early after myocardial infarction: correlation with myocardial perfusion and metabolism. | |
| | |
MedLine Citation:
|
PMID: 9285178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Abnormalities in wall thickening and their reaction to stimulation can be studied by magnetic resonance imaging. OBJECTIVE: To analyse the relationship between these abnormalities and changes in myocardial perfusion and fatty acid metabolism. METHODS: Fifteen patients with a myocardial infarction underwent low-dose dobutamine magnetic resonance imaging to assess their wall thickening and contractile reserve, and technetium-99m sestamibi (MIBI) and beta-methyl-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission tomography to assess their myocardial perfusion and fatty acid uptake. For nine segments per patient, the wall thickening was scored as normal, hypokinetic or akinetic, and the myocardial perfusion as normal (> 65%), mildly to moderately reduced (35-65%) or severely reduced (< 35%). Abnormalities in fatty acid uptake were compared with the myocardial perfusion and defined as matched (difference < or = 10%) or mismatched (difference > 10%) reduction. RESULTS: Thirty-four segments had abnormal wall thickening (13 hypokinetic and 21 akinetic). The wall thickening at rest was significantly related to the uptake of MIBI (P < 0.001), but not to abnormalities in the uptake of BMIPP. All of the akinetic segments had an abnormal uptake of MIBI (15 severely and six mildly to moderately reduced), whereas 7 of 13 hypokinetic segments had a normal and five a midly to moderately reduced uptake. A significant relationship between abnormalities of fatty acid metabolism and the contractile reserve was also found (P < 0.002): 14 of 16 segments with and only six of 18 without contractile reserve had a mismatched reduction in uptakes of MIBI and BMIPP. CONCLUSION: This study confirms the relationship between the wall thickening at rest and the residual perfusion after infarction. On the other hand, the contractile reserve, which is an accepted indicator of the viability of the infarct region, is associated strongly with abnormalities of fatty acid metabolism. |
| | |
Authors:
|
P Dendale; P R Franken; E E van der Wall; A de Roos |
Related Documents
:
|
572228 - Uptake of fatty acids by cultured cardiac cells from chick embryo: evidence for a facil... 7066178 - Reaction of cells cultured in vitro to different asbestos dusts of equal surface area b... 16124308 - Laboratory investigation of heterogeneous interaction of sulfuric acid with soot. 3114208 - Methionine and lysine uptake by cattle small intestine in vitro. 6851988 - Activities of enzymes of rat hepatic mitochondrial fatty acid oxidation during increase... 14612948 - Eicosapentaenoic acid perturbs signalling via the nfkappab transcriptional pathway in p... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Coronary artery disease Volume: 8 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 259-64 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, AZVUB, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cardiotonic Agents / diagnostic use Coronary Circulation* Dobutamine / diagnostic use Evaluation Studies as Topic Fatty Acids / diagnostic use, metabolism Female Humans Iodine Radioisotopes / diagnostic use Iodobenzenes / diagnostic use Magnetic Resonance Imaging Male Middle Aged Myocardial Contraction* Myocardial Infarction / pathology, physiopathology* Myocardium / pathology* Radiopharmaceuticals / diagnostic use Technetium Tc 99m Sestamibi / diagnostic use Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 116754-87-1/iodofiltic acid; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma endothelin-1 levels in non-insulin dependent diabetes mellitus patients with macrovascular di...
Next Document: Intravascular ultrasound assessment of direct percutaneous transluminal coronary angioplasty in pati...