Document Detail

Wall shear stress and related hemodynamic parameters in the fetal descending aorta derived from color Doppler velocity profiles.
MedLine Citation:
PMID:  16286023     Owner:  NLM     Status:  MEDLINE    
This paper presents a methodology for estimating the wall shear stress in the fetal descending aorta from color Doppler velocity profiles obtained during the second half of pregnancy. The Womersley model was applied to determine the wall shear stress and related hemodynamic parameters. Our analysis indicates that the aortic diameter can be modeled as a function of the gestational age in weeks as: Diameter (mm) = + 0.15 (R2 = 0.64, p < 0.001). The aortic volume flow showed a log linear gestational age-related increase that fit the model: F (mL/min) = e( + 3.49) (R2 = 0.61, p < 0.001). The Womersley number increased linearly with gestational age from 3.3 to 6.2 (p < 0.001) and the pressure gradient decreased linearly from 2.68 to 1.16 mPa/mm (p = 0.003) during the second half of pregnancy; the mean wall shear stress for the study group was 2.2 Pa (SD = 0.59) and was independent of gestational age. This study suggests that the size of the fetal aorta adapts to flow demands and maintains constant mean wall shear stress.
P C Struijk; P A Stewart; K L Fernando; V J Mathews; T Loupas; E A P Steegers; J W Wladimiroff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  31     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1441-50     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Aorta, Thoracic / embryology,  physiopathology,  ultrasonography*
Blood Pressure
Endothelial Cells / ultrasonography*
Fetal Growth Retardation / ultrasonography
Gestational Age
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Regional Blood Flow
Shear Strength
Ultrasonography, Doppler, Color*
Ultrasonography, Prenatal*

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