| Wall motion and perfusion analysis of transmyocardial laser revascularization. | |
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MedLine Citation:
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PMID: 12775308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Transmyocardial laser revascularization (TMLR) creates channels in the myocardium. The aim of the treatment is to relieve angina in patients with end-stage coronary artery disease. We studied the effect of TMLR on myocardial function and perfusion with the combination of cine magnetic resonance imaging (MRI) and thallium scintigraphy. DESIGN: Eight patients with severe triple-vessel coronary artery disease were studied with MRI and thallium scintigraphy before and 6 months after laser treatment. RESULTS: TMLR did not improve global left ventricular (LV) function or myocardial perfusion. However, systolic wall thickening deprived in segments with fixed perfusion defects in 6 months and laser treatment prevented this deprivation (p = 0.03). In addition single photon emission computed tomography (SPECT) imaging indicated that TMLR prevented conversion of reversible into fixed defects. CONCLUSION: In severe, progressing coronary artery disease TMLR does not improve global LV function or myocardial perfusion, but it preserves systolic wall thickening in fixed defects (scar). It also prevents changes from ischemic myocardial regions to scar. |
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Authors:
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Miia Holmström; Helena Hänninen; Jarmo Simpanen; Kari S Virtanen; Kalervo Werkkala; Hannu J Aronen; Kirsi Lauerma |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 37 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-30 Completed Date: 2003-12-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: Norway |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Helsinki University Central Hospital, Finland. Miia.Holmstrom@hus.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Disease / physiopathology*, radionuclide imaging, surgery* Coronary Circulation* Exercise Female Follow-Up Studies Heart / physiopathology*, radionuclide imaging Humans Lasers* Magnetic Resonance Imaging Male Middle Aged Myocardial Revascularization* Perfusion Thallium |
| Chemical | |
Reg. No./Substance:
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7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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