Document Detail


Walking economy in people with Parkinson's disease.
MedLine Citation:
PMID:  19441128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gait dysfunction is an early problem identified by patients with Parkinson's disease (PD). Alterations in gait may result in an increase in the energy cost of walking (i.e., walking economy). The purpose of this study was to determine whether walking economy is atypical in patients with PD when compared with healthy controls. A secondary purpose was to evaluate the associations of age, sex, and level of disease severity with walking economy in patients with PD. The rate of oxygen consumption (VO(2)) and other responses to treadmill walking were compared in 90 patients (64.4 +/- 10.3 years) and 44 controls (64.6 +/- 7.3 years) at several walking speeds. Pearson correlation coefficients (r) were calculated to determine relationships of age, sex, and disease state with walking economy in PD patients. Walking economy was significantly worse in PD patients than in controls at all speeds above 1.0 mph. Across all speeds, VO(2) was 6 to 10% higher in PD patients. Heart rate, minute ventilation, respiratory exchange ratio, and rating of perceived exertion were correspondingly elevated. No significant relationship of age, sex, or UPDRS score with VO(2) was found for patients with PD. The findings suggest that the physiologic stress of daily physical activities is increased in patients with early to mid-stage PD, and this may contribute to the elevated level of fatigue that is characteristic of PD.
Authors:
Cory L Christiansen; Margaret L Schenkman; Kim McFann; Pamela Wolfe; Wendy M Kohrt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-22     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1481-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Movement Disorder Society.
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MeSH Terms
Descriptor/Qualifier:
Aged
Exercise Test / methods
Female
Heart Rate / physiology
Humans
Male
Middle Aged
Oxygen Consumption / physiology*
Parkinson Disease / physiopathology*
Severity of Illness Index
Statistics as Topic
Walking / physiology*
Grant Support
ID/Acronym/Agency:
1 R01 HD043770/HD/NICHD NIH HHS; R01 HD043770/HD/NICHD NIH HHS; R01 HD043770-05S1/HD/NICHD NIH HHS
Comments/Corrections

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