Document Detail


Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.
MedLine Citation:
PMID:  23632918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
WalK, a histidine kinase, and WalR, a response regulator, make up a two-component signal transduction system that is indispensable for the cell-wall metabolism of low GC Gram-positive bacteria. WalK inhibitors are likely to show bactericidal effects against methicillin-resistant Staphylococcus aureus . We discovered a new WalK inhibitor, designated waldiomycin, by screening metabolites from actinomycetes. Waldiomycin belongs to the family of angucycline antibiotics and is structurally related to dioxamycin. Waldiomycin inhibits WalK from S. aureus and Bacillus subtilis at IC50s 8.8 and 10.2 μM, respectively, and shows antibacterial activity with MICs ranging from 4 to 8 μg ml(-1) against methicillin-resistant S. aureus and B. subtilis.The Journal of Antibiotics advance online publication, 1 May 2013; doi:10.1038/ja.2013.33.
Authors:
Masayuki Igarashi; Takafumi Watanabe; Tomohiro Hashida; Maya Umekita; Masaki Hatano; Yohei Yanagida; Hirokazu Kino; Tomoyuki Kimura; Naoko Kinoshita; Kunio Inoue; Ryuichi Sawa; Yoshio Nishimura; Ryutaro Utsumi; Akio Nomoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-01
Journal Detail:
Title:  The Journal of antibiotics     Volume:  -     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan.
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