| Wakame and Nori in restructured meats included in cholesterol-enriched diets affect the antioxidant enzyme gene expressions and activities in Wistar rats. | |
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MedLine Citation:
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PMID: 20676937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of diets including restructured meats (RM) containing Wakame or Nori on total liver glutathione status, and several antioxidant enzyme gene expressions and activities were tested. Six groups of ten male growing Wistar rats each were fed a mix of 85% AIN-93 M diet and 15% freeze-dried RM for 35 days. The control group (C) consumed control RM, the Wakame (W) and the Nori (N) groups, RM with 5% Wakame and 5% Nori, respectively. Animals on added cholesterol diets (CC, CW, and CN) consumed their corresponding basal diets added with cholesterol (2%) and cholic acid (0.4%). Alga and dietary cholesterol significantly interact (P < 0.002) influencing all enzyme expressions but not activities. The cholesterol supplement decreased most enzyme expression and activity. W-RM vs. C-RM increased (P < 0.05) expression of GPx, GR, Mn-SOD, and Cu,Zn-SOD and decreased that of catalase. N-RM vs. C-RM increased (P < 0.05) expression of catalase and Mn-SOD. GR activity increased in W-RM rats while SOD activity increased, but that of Se-GPx decreased in N animals. W-RM increased total and reduced glutathione and decreased the redox index. CN diet induced significantly lower plasma cholesterol levels (P < 0.001) than the CW diet. In conclusion, Nori-RM is a hypocholesterolemic food while Wakame-RM is an antioxidant food. This should be taken into account when including this kind of RM as potential functional foods in human. |
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Authors:
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Adriana Schultz Moreira; Laura González-Torres; Raul Olivero-David; Sara Bastida; Juana Benedi; Francisco J Sánchez-Muniz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Plant foods for human nutrition (Dordrecht, Netherlands) Volume: 65 ISSN: 1573-9104 ISO Abbreviation: Plant Foods Hum Nutr Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803554 Medline TA: Plant Foods Hum Nutr Country: Netherlands |
Other Details:
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Languages: eng Pagination: 290-8 Citation Subset: IM |
Affiliation:
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Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology Antioxidants / metabolism*, pharmacology Cholesterol, Dietary / administration & dosage, blood, pharmacology* Cholic Acid Enzymes / genetics, metabolism* Functional Food Gene Expression Male Meat Products* Oxidative Stress Phytotherapy Plant Preparations / pharmacology* Porphyra* Rats Rats, Wistar Undaria* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antioxidants; 0/Cholesterol, Dietary; 0/Enzymes; 0/Plant Preparations; 81-25-4/Cholic Acid |
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