Document Detail


Waist-to-hip ratio is associated with pulmonary gas exchange in the morbidly obese.
MedLine Citation:
PMID:  17296634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Morbidly obese individuals (ie, body mass index [BMI], > or = 40 kg/m2) may have a pulmonary gas exchange impairment due to the large fat mass surrounding their abdomen. PURPOSES: To examine the effect of the waist-to-hip (W/H) ratio on pulmonary gas exchange in the morbidly obese. METHODS: Twenty-five morbidly obese individuals (mean [+/- SD] age, 39 +/- 10 years; mean BMI, 49 +/- 7 kg/m2; mean body fat, 50 +/- 6%; mean waist circumference, 135 +/- 15 cm; mean W/H ratio, 0.97 +/- 0.11) scheduled for bariatric surgery were recruited. Arterial blood was sampled in duplicate after 5 min of rest sitting upright. RESULTS: The mean PaO2 at rest was 88 +/- 7 mm Hg (range, 72 to 108 mm Hg), the alveolar-arterial oxygen pressure difference (P[A-a]O2) was 19 +/- 9 mm Hg (range, 1 to 37 mm Hg), and the PacO2 was 38 +/- 3 mm Hg (range, 32 to 44 mm Hg). Linear regression showed that 32% and 36%, respectively, of the variance in the P(A-a)O2 and PaO2 were explained by the W/H ratio (p < 0.004 for both). As well, 20% of the variance in PacO2 was explained by the W/H ratio (p = 0.02). Men had larger W/H ratios (p < 0.01) and poorer gas exchange (p = 0.06) compared to women (mean difference: PaO2, -7 mm Hg; P[A-a]O2, 6 mm Hg). CONCLUSION: Morbidly obese men showed a trend to have poorer pulmonary gas exchange compared to morbidly obese women, and a significant part of the blood gas status in these patients is associated with the W/H ratio.
Authors:
Gerald S Zavorsky; Juan M Murias; Do Jun Kim; Jennifer Gow; Jean-Loup Sylvestre; Nicolas V Christou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  131     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-13     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, McGill University Health Center, Montreal General Hospital, 1650 Cedar Ave, Room D10-144, Montreal, QC, Canada H3G 1A4. gerald.zavorsky@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Gas Analysis
Body Mass Index
Female
Humans
Male
Middle Aged
Obesity, Morbid / blood,  physiopathology*
Posture / physiology
Pulmonary Gas Exchange / physiology*
Rest / physiology
Sex Factors
Waist-Hip Ratio*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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