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Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients.
MedLine Citation:
PMID:  21188241     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objectives. The primary objective of this study was to determine the relationship between waist-to-hip ratio (WHR), cardiovascular (CV) events, and mortality in peritoneal dialysis (PD) patients. A secondary objective was to investigate the association between abdominal obesity and systemic inflammatory markers. Methods. This is a prospective study of 22 prevalent PD patients. WHR was measured at baseline. C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured. Main outcomes were first CV event and death from all causes. Survival analysis was used to examine the relationship between anthropomorphic measures and clinical outcomes. Results. Mean follow-up period was 3.1 years. In Kaplan-Meier analysis, survival was lower in those with higher WHR (P = .002). In Cox regression, WHR independently predicted mortality and first CV event after adjustment for known ischemic heart disease (hazard ratio [HR] 1.17, confidence interval [CI] 1.05-1.30 for death; HR 1.13, CI 1.01-1.26 for CV event). WHR correlated with serum TNF-α (r = 0.45; P = .05). Conclusion. The results of this study suggest WHR may be a risk factor for increased CV events and mortality in PD patients. Abdominal obesity is also associated with inflammatory markers. Larger studies are warranted to confirm these findings.
Authors:
Winnie S Su; Catherine M Clase; K Scott Brimble; Peter J Margetts; Trevor J Wilkieson; Azim S Gangji
Publication Detail:
Type:  Journal Article     Date:  2010-07-05
Journal Detail:
Title:  International journal of nephrology     Volume:  2010     ISSN:  2090-2158     ISO Abbreviation:  Int J Nephrol     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101546753     Medline TA:  Int J Nephrol     Country:  England    
Other Details:
Languages:  eng     Pagination:  831243     Citation Subset:  -    
Affiliation:
Division of Nephrology, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada L8N 4A6.
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