| The WSX-1 pathway restrains intestinal T-cell immunity. | |
| | |
MedLine Citation:
|
PMID: 21233255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mechanisms regulating intestinal T-cell accumulation during inflammation have considerable therapeutic value. In this study, LPS increased Staphylococcus aureus enterotoxin A-specific T cells in the gut through induction of IL-12 family members. Mice deficient in IL-12 (p35(-/-)) favored T(h)17 differentiation in lamina propria, whereas mice lacking both IL-12 and IL-23 (p40(-/-)) produced significantly fewer T(h)17 cells. However, serum analysis revealed that IL-27p28 was much higher and sustained following LPS injection than other IL-12 family cytokines. Strikingly, WSX-1 (IL-27Rα) deficiency resulted in log-fold increases in lamina propria T(h)17 cells without affecting T(h)1 numbers. These results may be explained by increased expression of α4β7 on WSX-1-deficient T cells after immunization. WSX-1-deficient regulatory T cells (Tregs) were also perturbed, producing more IL-17 and less IL-10 than wild-type Tregs. Thus, IL-27 blockade may provide a new pathway to improve mucosal vaccination. |
| | |
Authors:
|
Jeremy P McAleer; Christiaan J M Saris; Anthony T Vella |
Related Documents
:
|
21339485 - Reversal of hyperlipidemia with a genetic switch favorably affects the content and infl... 10654945 - Impaired germinal center reaction in mice with short telomeres. 21740565 - A comprehensive characterization of the caspase gene family in insects from the order l... 10200535 - Tnfalpha-mediated cell death is independent of cdc25a. 16517165 - Protective tolerance to fungi: the role of il-10 and tryptophan catabolism. 22119805 - Overexpression of microrna-378 attenuates ischemia-induced apoptosis by inhibiting casp... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-13 |
Journal Detail:
|
Title: International immunology Volume: 23 ISSN: 1460-2377 ISO Abbreviation: Int. Immunol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-01 Completed Date: 2011-05-26 Revised Date: 2012-02-01 |
Medline Journal Info:
|
Nlm Unique ID: 8916182 Medline TA: Int Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 129-37 Citation Subset: IM |
Affiliation:
|
Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
pharmacology Animals Flow Cytometry Gene Expression Regulation / drug effects Interleukin-12 / genetics, immunology* Interleukin-23 / genetics, immunology Intestines / immunology* Lipopolysaccharides / pharmacology Mice Mice, Inbred C57BL Mice, Knockout Receptors, Cytokine / genetics, immunology* Signal Transduction T-Lymphocytes / drug effects, immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01-AI42858/AI/NIAID NIH HHS; R01-AI52108/AI/NIAID NIH HHS; T32-AI07080/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 0/Il27ra protein, mouse; 0/Interleukin-23; 0/Lipopolysaccharides; 0/Receptors, Cytokine; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblas...
Next Document: Predictors of early versus late smoking abstinence within a 24-month disease management program.