Document Detail

WITHDRAWN: Maternal iodine supplements in areas of deficiency.
MedLine Citation:
PMID:  17636600     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iodine deficiency is the leading preventable cause of intellectual impairment in the world. Although iodine supplementation is generally considered to be safe, there is a possibility of high doses of iodine suppressing maternal thyroid function.
OBJECTIVES: The objective of this review was to assess the effects of iodine supplementation before or during pregnancy in areas of iodine deficiency.
SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register.
SELECTION CRITERIA: All acceptably controlled trials of maternal iodine supplementation during pregnancy with clinical outcomes.
DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed by two reviewers.
MAIN RESULTS: Three trials involving 1551 women were included. In two trials, iodine supplementation was associated with a statistically significant reduction in deaths during infancy and early childhood (relative risk 0.71, 95% confidence interval 0.56 to 0.90). Iodine supplementation was associated with decreased prevalence of endemic cretinism at the age of four years (relative risk 0.27, 95% confidence interval 0.12 to 0.60) and better psychomotor development scores between four to 25 months of age.
AUTHORS' CONCLUSIONS: Iodine supplementation in a population with high levels of endemic cretinism results in an important reduction in the incidence of the condition with no apparent adverse effects.
K Mahomed; A M Gülmezoglu
Publication Detail:
Type:  Journal Article; Review     Date:  2007-07-18
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2006  
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD000135     Citation Subset:  IM    
Ipswich Hospital, Ipswich, Queensland, Australia, 4305.
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MeSH Terms
Child, Preschool
Congenital Hypothyroidism / prevention & control*
Deficiency Diseases / prevention & control
Dietary Supplements*
Iodine* / deficiency
Preconception Care
Prenatal Care
Reg. No./Substance:
Update Of:
Cochrane Database Syst Rev. 2000;(2):CD000135   [PMID:  10796152 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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