| WITHDRAWN: Maternal iodine supplements in areas of deficiency. | |
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MedLine Citation:
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PMID: 17636600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Iodine deficiency is the leading preventable cause of intellectual impairment in the world. Although iodine supplementation is generally considered to be safe, there is a possibility of high doses of iodine suppressing maternal thyroid function. OBJECTIVES: The objective of this review was to assess the effects of iodine supplementation before or during pregnancy in areas of iodine deficiency. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register. SELECTION CRITERIA: All acceptably controlled trials of maternal iodine supplementation during pregnancy with clinical outcomes. DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed by two reviewers. MAIN RESULTS: Three trials involving 1551 women were included. In two trials, iodine supplementation was associated with a statistically significant reduction in deaths during infancy and early childhood (relative risk 0.71, 95% confidence interval 0.56 to 0.90). Iodine supplementation was associated with decreased prevalence of endemic cretinism at the age of four years (relative risk 0.27, 95% confidence interval 0.12 to 0.60) and better psychomotor development scores between four to 25 months of age. AUTHORS' CONCLUSIONS: Iodine supplementation in a population with high levels of endemic cretinism results in an important reduction in the incidence of the condition with no apparent adverse effects. |
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Authors:
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K Mahomed; A M Gülmezoglu |
Publication Detail:
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Type: Journal Article; Review Date: 2007-07-18 |
Journal Detail:
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Title: Cochrane database of systematic reviews (Online) Volume: - ISSN: 1469-493X ISO Abbreviation: Cochrane Database Syst Rev Publication Date: 2006 |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-10-18 Revised Date: 2007-10-25 |
Medline Journal Info:
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Nlm Unique ID: 100909747 Medline TA: Cochrane Database Syst Rev Country: England |
Other Details:
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Languages: eng Pagination: CD000135 Citation Subset: IM |
Affiliation:
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Ipswich Hospital, Ipswich, Queensland, Australia, 4305. kassam_mahomed@health.qld.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Congenital Hypothyroidism / prevention & control* Deficiency Diseases / prevention & control Dietary Supplements* Female Humans Infant Iodine* / deficiency Preconception Care Pregnancy Prenatal Care |
| Chemical | |
Reg. No./Substance:
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7553-56-2/Iodine |
| Comments/Corrections | |
Update Of:
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Cochrane Database Syst Rev. 2000;(2):CD000135
[PMID:
10796152
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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