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WITHDRAWN: Maternal antigen avoidance during lactation for preventing atopic disease in infants of women at high risk.
MedLine Citation:
PMID:  17636599     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Background pending.
OBJECTIVES: To assess the effects of prescribing an antigen avoidance diet during lactation on the nutritional status of the mother and newborn and on the development of atopic disease in the child. The main focus is on women whose infants are at high risk for developing an atopic condition, based on a history of atopic disease in the mother, father, or a previous child.
SEARCH STRATEGY: The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group. Date of last search: October 2001.
SELECTION CRITERIA: All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating women at high risk, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. Trials of multimodal interventions that include manipulation of the infant's diet other than breast milk or of other nondietary aspects of the infant's environment (eg, exposure to inhaled allergens) have been excluded from the review.
DATA COLLECTION AND ANALYSIS: Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author.
MAIN RESULTS: Three trials involving 209 women were included. The combined data from the three available trials suggest a strong protective effect of maternal antigen avoidance on the incidence of atopic eczema during the child's first 12-18 months of life. Methodologic shortcomings in all three trials, however, argue for caution in applying these encouraging results. In particular, the high incidence of atopic eczema in the control groups of all three trials might be explained by nonblinding or de-blinding of the examining physicians.
AUTHORS' CONCLUSIONS: Prescription of an antigen avoidance diet to a high-risk woman during lactation may substantially reduce her child's risk of developing atopic eczema, but better trials are needed.
M S Kramer
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-07-18
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  1996  
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD000132     Citation Subset:  IM    
McGill University, Faculty of Medicine, 1020 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A2.
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MeSH Terms
Dietary Proteins*
Hypersensitivity, Immediate / epidemiology,  prevention & control*
Infant, Newborn
Lactation* / immunology
Risk Factors
Reg. No./Substance:
0/Dietary Proteins
Update Of:
Cochrane Database Syst Rev. 2000;(2):CD000132   [PMID:  10796149 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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