| WITHDRAWN: Cell cycle Inhibition as a Strategy for Treatment of Central Nervous System Diseases. | |
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MedLine Citation:
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PMID: 19534699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ahead of Print article withdrawn by publisher. Classically, the cell cycle is regarded as the central process leading to cellular proliferation. However, increasing evidence has substantiated the concept that cell cycle re-entry by neurons leads to post-mitotic death. A neuron that re-enters the cell cycle can neither advance to a new G0 quiescent state nor revert to its earlier G0 state. This presents a critical dilemma to the neuron from which death may be an unavoidable, but necessary, outcome for adult neurons attempting to complete the cell cycle. In this review we summarize the signal transduction events and mitogenic molecules that can drive the neuron into the cell cycle in various CNS diseases, and discuss the hypthesis that two main requirements are to be met for neuronal cell cycle re-entry: (1) an elevation in cell cycle proteins and (2) increased pro-mitogenic signals. Pharmacological approaches and patents are outlined that interfere with the mitogenic pathways, prevent mature neurons from attempted cell cycle re-entry, and protect them from cell death. |
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Authors:
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Da-Zhi Liu; Bradley P Ander; Frank R Sharp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-11-1 |
Journal Detail:
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Title: Recent patents on nanotechnology Volume: - ISSN: - ISO Abbreviation: - Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291922 Medline TA: Recent Pat Nanotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurology and the M.I.N.D. Institute, University of California at Davis, Sacramento, California 95817, CA, USA. dzliu@ucdavis.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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