| WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy. | |
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MedLine Citation:
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PMID: 21069664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: While not common, itching in pregnancy (not due to liver disease) can be distressing. OBJECTIVES: The objective of this review was to assess the effects of treatment for itching in late pregnancy. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register (January 2007). SELECTION CRITERIA: Randomised trials of treatments for itching in women in late pregnancy with normal liver function. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. MAIN RESULTS: One study of 38 women was included. This was a small crossover trial, using alternate allocation. The trial compared a histamine, chlorpheniramine, with aspirin. Aspirin was more effective than chlorpheniramine in relieving itching (odds ratio 2.39, 95% confidence interval 1.25 to 4.57). However, chlorpheniramine was more effective than aspirin when a rash was present. AUTHORS' CONCLUSIONS: Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present. If there is a rash, chlorpheniramine may be more effective. |
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Authors:
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Gavin Young; David Jewell |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-11-10 |
Journal Detail:
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Title: Cochrane database of systematic reviews (Online) Volume: - ISSN: 1469-493X ISO Abbreviation: Cochrane Database Syst Rev Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2010-12-06 Revised Date: 2011-03-09 |
Medline Journal Info:
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Nlm Unique ID: 100909747 Medline TA: Cochrane Database Syst Rev Country: England |
Other Details:
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Languages: eng Pagination: CD000027 Citation Subset: IM |
Affiliation:
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Temple Sowerby Medical Practice, Linden Park, Temple Sowerby, Penrith, Cumbria, UK, CA10 1RW. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antipruritics
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therapeutic use* Aspirin / therapeutic use* Chlorpheniramine / therapeutic use* Female Histamine H1 Antagonists / therapeutic use* Humans Pregnancy Pregnancy Complications / drug therapy* Pregnancy Trimester, Third Pruritus / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipruritics; 0/Histamine H1 Antagonists; 132-22-9/Chlorpheniramine; 50-78-2/Aspirin |
| Comments/Corrections | |
Update Of:
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Cochrane Database Syst Rev. 2000;(2):CD000027
[PMID:
10796091
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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