Document Detail

WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy.
MedLine Citation:
PMID:  21069664     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While not common, itching in pregnancy (not due to liver disease) can be distressing.
OBJECTIVES: The objective of this review was to assess the effects of treatment for itching in late pregnancy.
SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register (January 2007).
SELECTION CRITERIA: Randomised trials of treatments for itching in women in late pregnancy with normal liver function.
DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data.
MAIN RESULTS: One study of 38 women was included. This was a small crossover trial, using alternate allocation. The trial compared a histamine, chlorpheniramine, with aspirin. Aspirin was more effective than chlorpheniramine in relieving itching (odds ratio 2.39, 95% confidence interval 1.25 to 4.57). However, chlorpheniramine was more effective than aspirin when a rash was present.
AUTHORS' CONCLUSIONS: Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present. If there is a rash, chlorpheniramine may be more effective.
Gavin Young; David Jewell
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-11-10
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-11     Completed Date:  2010-12-06     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD000027     Citation Subset:  IM    
Temple Sowerby Medical Practice, Linden Park, Temple Sowerby, Penrith, Cumbria, UK, CA10 1RW.
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MeSH Terms
Antipruritics / therapeutic use*
Aspirin / therapeutic use*
Chlorpheniramine / therapeutic use*
Histamine H1 Antagonists / therapeutic use*
Pregnancy Complications / drug therapy*
Pregnancy Trimester, Third
Pruritus / drug therapy*
Reg. No./Substance:
0/Antipruritics; 0/Histamine H1 Antagonists; 132-22-9/Chlorpheniramine; 50-78-2/Aspirin
Update Of:
Cochrane Database Syst Rev. 2000;(2):CD000027   [PMID:  10796091 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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