Document Detail

WISE 2005: vascular responses to 60-day bed rest in women.
MedLine Citation:
PMID:  18372696     Owner:  NLM     Status:  MEDLINE    
WISE-2005 studied 24 women during a 60-day head down bed rest (HDBR) who look part in an exercise countermeasure (LBNP-treadmill plus flywheel, EX) and no-exercise (No-EX). We conducted a series of experiments to explore changes in cardiovascular function and the ability of EX to prevent these changes. Resting arterial diameter in the arm was not affected but the leg arteries (femoral and popliteal) were significantly reduced in Np-EX, but was increased in EX. In this study we report on drug stimulated responses with sublingual nitroglycerin and infused isoproterenol. Heart rate increased in response to nitroglycerin with larger increases in No-EX after HDBR. Likewise during isoproterenol infusion the HR increase was greater after HDBR in the No-EX group. In all cases, the higher HR was associated with lower stroke volume in No-EX while stroke volume was protected in EX. These data do not support a change in sensitivity of beta-adrenergic receptors after HDBR. The leg vascular resistance decreased in response to isoproterenol and it decreased to a greater extent in No-EX than EX. These data were consistent with observations of lower leg vascular resistance during orthostatic challenge tests after HDBR. We conclude that consistent changes in cardiovascular function in the No-EX were detected by different methods that point to mechanisms contributing to orthostatic intolerance after HDBR.
R L Hughson; J K Shoemaker; Ph Arbeille; K S Dyson; H Edgell; P Kerbeci; L Mattar; K Zuj; D K Greaves
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology     Volume:  14     ISSN:  1077-9248     ISO Abbreviation:  J Gravit Physiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437868     Medline TA:  J Gravit Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  P53-4     Citation Subset:  IM    
Cardiorespiratory & Vascular Dynamics Lab, Univ. Waterloo, Waterloo, Ontario, Canada.
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage
Bed Rest / adverse effects*
Cardiac Output
Cardiovascular Deconditioning*
Dietary Proteins / administration & dosage
Dizziness / etiology,  physiopathology,  prevention & control*
Femoral Artery / drug effects,  physiopathology*
Head-Down Tilt / adverse effects
Heart Rate
Isoproterenol / administration & dosage
Lower Body Negative Pressure
Nitroglycerin / administration & dosage
Popliteal Artery / drug effects,  physiopathology*
Space Flight
Stroke Volume
Time Factors
Vascular Resistance
Vasodilator Agents / administration & dosage
Weightlessness Countermeasures*
Weightlessness Simulation
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Dietary Proteins; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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