Document Detail

WISE-2005: exercise and nutrition countermeasures for upright VO2pk during bed rest.
MedLine Citation:
PMID:  19915502     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Exercise prescriptions for spaceflight include aerobic and resistive countermeasures, yet few studies have evaluated their combined effects on exercise responses after real or simulated microgravity. We hypothesized that upright aerobic capacity (VO2pk) is protected during a 60-d bed rest (BR) in which intermittent (40%-80% pre-BR VO2pk) aerobic exercise (supine treadmill exercise against lower body negative pressure) was performed 2-4 d x wk(-1) and resistive exercise (inertial flywheel exercises) was performed 2-3 d x wk(-1). Further, we hypothesized that ingestion of an amino acid supplement that was shown previously to counteract muscle atrophy, would reduce the decline in VO2pk in nonexercising subjects during BR. METHODS: Twenty-four healthy women (8 nonexercise controls (CON), 8 exercisers (EX), and 8 nonexercisers with nutritional supplementation (NUT)) underwent a 20-d ambulatory baseline period, 60 d of 6 degrees head-down tilt BR, and 21 d of ambulatory recovery. VO2pk was measured pre-BR and on the third day of recovery from BR (R3). RESULTS: In the EX group, VO2pk (mean +/- SE) was not different from pre-BR (-3.3 +/- 1.2%) on R3, although it decreased significantly in the CON (-21.2 +/- 2.1%) and NUT (-25.6 +/- 1.6%) groups. CONCLUSIONS: These results indicate that alternating aerobic and resistive exercise on most days during prolonged microgravity simulated by BR is sufficient to preserve or allow quick recovery of upright aerobic capacity in women but that a nutritional supplementation alone is not effective.
Suzanne M Schneider; Stuart M C Lee; Brandon R Macias; Donald E Watenpaugh; Alan R Hargens
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  41     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2165-76     Citation Subset:  IM; S    
Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM 87131-0001, USA.
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MeSH Terms
Bed Rest / adverse effects*
Dietary Supplements*
Exercise / physiology*
Exercise Test
Nutritional Requirements
Oxygen Consumption / physiology*
Treatment Outcome
Weightlessness Countermeasures*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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