| WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. I. Fermentation and isolation. | |
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MedLine Citation:
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PMID: 7515037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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WIN 64821, a nonpeptide neurokinin antagonist, was isolated from a strain of Aspergillus sp., SC319. The compound was produced in different fermentation media with greatest yields observed when the culture was grown in a synthetic medium supplemented with L-tryptophan and L-phenylalanine. After 6 days fermentation, yields greater than 600 mg/liter were obtained. Two analogs of WIN 64821 were also identified in the culture extracts and subsequently tested for biological activity. WIN 64821 was the most potent compound isolated from this culture and exhibited activity as a substance P-binding inhibitor with submicromolar potency against the human neurokinin 1 receptor. |
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Authors:
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D M Sedlock; C J Barrow; J E Brownell; A Hong; A M Gillum; D R Houck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 47 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-06-30 Completed Date: 1994-06-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 391-8 Citation Subset: IM |
Affiliation:
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Sterling Winthrop Pharmaceuticals Research Division, Collegeville, PA 19426-0900. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillus
/
classification,
growth & development,
metabolism* Astrocytoma / metabolism Binding Sites Chromatography, High Pressure Liquid Culture Media Fermentation Humans Indoles / chemistry, isolation & purification*, metabolism, pharmacology Piperazines / chemistry, isolation & purification*, metabolism, pharmacology Spectrometry, Mass, Fast Atom Bombardment Substance P / antagonists & inhibitors*, metabolism Tryptophan / chemistry Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Indoles; 0/Piperazines; 150881-27-9/WIN 64821; 33507-63-0/Substance P; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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