Document Detail

The WHO multicentre trial of the vasopressor effects of combined oral contraceptives: 2. Lack of effect of estrogen. Task Force on Oral Contraceptives. WHO Special Programme of Research, Development and Research Training in Human Reproduction.
MedLine Citation:
PMID:  2503295     Owner:  NLM     Status:  MEDLINE    
Changes in blood pressure were measured in a randomized double-blind trial of 680 women using oral contraceptives containing either 50 or 30 ug of ethinyl estradiol combined with 250 mg levonorgestrel. The trial was done in 6 centres in Thailand, India, Zambia, Cuba, The Philippines, and Hungary. There were no significant differences between the two pills at any of 4 follow-up visits at approximately 3, 6, 9 and 12 months, nor in the life-table probability of developing hypertension within one year. These findings are evidence against the hypothesis that it is the estrogen in oral contraceptives which causes their vasopressor effect.
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Contraception     Volume:  40     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-19     Completed Date:  1989-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Contraceptives, Oral, Combined / adverse effects*
Ethinyl Estradiol / adverse effects*
Multicenter Studies as Topic
Norgestrel / adverse effects*
Time Factors
World Health Organization
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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