| WHIM syndrome and oral squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 19926501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is an autosomal dominant disease related to a mutation in the chemokine receptor CXCR4 resulting in altered immune function. An increased susceptibility in these patients to human papillomavirus (HPV) manifests as cutaneous warts and, in women, cervical dysplasia and squamous carcinoma. HPV-related squamous carcinoma in other sites has not been documented. We report the occurrence of HPV-related squamous cell carcinoma of the oral cavity in 2 siblings with WHIM syndrome, whose pedigree has previously been described. |
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Authors:
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Nicole A Cipriani; Elizabeth Blair; Jerome B Taxy |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 109 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 105-8 Citation Subset: D; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pathology, University of Chicago Medical Center, Chicago, Illinois 60637, USA. nicole.cipriani@uchospitals.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agammaglobulinemia / complications*, immunology Bacterial Infections / complications, immunology Bone Marrow Cells / pathology Carcinoma, Squamous Cell / etiology* Female Humans Immunohistochemistry Male Middle Aged Mouth Neoplasms / etiology* Neoplasm Proteins / analysis Siblings Syndrome Warts / complications*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/P16 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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