| Vulvovaginal pellagra and lichen sclerosus complicating carcinoid syndrome. | |
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MedLine Citation:
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PMID: 19155950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pellagra is a rare clinical syndrome caused by niacin deficiency, and although most commonly nutritional in origin, may be secondary to carcinoid syndrome. CASE: A premenopausal nulliparous woman with metastatic carcinoid tumor developed isolated vulvovaginal manifestations characterized by well-demarcated symmetrical vulvar erythema, mild scaling, ulcerations, and dyspareunia. Tryptophan levels were low. Treatment with nicotinamide resulted in dramatic improvement; however, after 2 years of effective treatment, she developed lichen sclerosus. CONCLUSION: Patients with carcinoid tumor presenting chronic vulvar lesions should be evaluated for pellagra. Subsequent development of lichen sclerosus at the site of vulvar dermatosis may be a feature of the "Koebner phenomenon," which describes appearance of lichen sclerosus in scarred areas or sites prone to friction. |
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Authors:
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Orna Reichman; Jack D Sobel |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 113 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-21 Completed Date: 2009-02-23 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 543-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA. orna.reich@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Candidiasis, Vulvovaginal
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diagnosis* Diagnostic Errors* Female Humans Malignant Carcinoid Syndrome / complications* Niacin / therapeutic use Pellagra / complications*, diagnosis, drug therapy Premenopause Vitamins / therapeutic use Vulvar Lichen Sclerosus / complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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