| Vulvar verruciform xanthoma: ten cases associated with lichen sclerosus, lichen planus, or other conditions. | |
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MedLine Citation:
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PMID: 21576553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Verruciform xanthoma (VX) is a rare benign tumor that usually involves the oral cavity. Since the first report of this tumor in 1971, only 9 cases have been reported on the vulva, and 3 of these were associated with another vulvar condition. We describe the clinicopathologic features of 10 patients with vulvar VX and focus on their associated conditions. OBSERVATION: The mean age of the patients was 68 years (range, 51-80 years). The VX lesions were asymptomatic, yellowish-orange verrucous plaques. The diagnosis was clinically suspected in 2 cases; other suggested diagnoses were condyloma or squamous cell carcinoma. All of the patients had an associated vulvar condition: lichen sclerosus (6 patients), lichen planus (2 patients), Paget disease, or radiodermatitis. Under microscopy, the VX lesions displayed parakeratosis, acanthosis without atypia, and elongated rete ridges. Xanthomatous cells were aggregated in the papillary dermis. CONCLUSIONS: Vulvar VX is a benign tumor with misleading clinical features. All 10 cases were associated with a vulvar condition, mainly a lichen sclerosus. Therefore, VX might represent a reaction pattern induced by different conditions, mainly characterized by damage to the dermoepidermal junction. When confronted with the diagnosis of vulvar VX, clinicians may look for an associated vulvar condition. |
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Authors:
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Charlotte Fite; Françoise Plantier; Nicolas Dupin; Marie-Françoise Avril; Micheline Moyal-Barracco |
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Publication Detail:
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Type: Journal Article Date: 2011-05-16 |
Journal Detail:
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Title: Archives of dermatology Volume: 147 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-20 Completed Date: 2011-11-15 Revised Date: 2012-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1087-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Assistance Publique des Hôpitaux de Paris, Hospital Cochin, Paris Descartes University, Paris, France. charlotte.fite@noos.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Diagnosis, Differential Female Humans Lichen Planus / complications* Lichen Sclerosus et Atrophicus / complications* Middle Aged Paget Disease, Extramammary / complications Radiodermatitis / complications Vulvar Diseases / complications*, diagnosis, pathology Vulvar Neoplasms / diagnosis Warts / diagnosis, pathology Xanthomatosis / complications*, diagnosis, pathology |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 2012 Feb;148(2):260-2; author reply 262
[PMID:
22351836
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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