Document Detail


Vulpinic acids as potential antiinflammatory agents. 1. Vulpinic acids with substituents in the aromatic rings.
MedLine Citation:
PMID:  1120988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preparation of a series of vulpinic acids, substituted in either or both of the aromatic rings, is described. The compounds were found to be active in the adjuvant arthritis test in rats. High activity combined with an acceptable therapeutic ratio was confined to analogs with electron-withdrawing substituents in the meta positions of the rings.
Authors:
F R Foden; J McCormick; D M O'Mant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  18     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-06-20     Completed Date:  1975-06-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / adverse effects,  chemical synthesis*,  therapeutic use
Arthritis, Rheumatoid / drug therapy,  immunology
Benzylidene Compounds / adverse effects,  chemical synthesis,  therapeutic use
Dose-Response Relationship, Drug
Freund's Adjuvant
Hyperventilation / chemically induced
Pyrans / chemical synthesis*
Pyrones / adverse effects,  chemical synthesis*,  therapeutic use
Rats
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Benzylidene Compounds; 0/Pyrans; 0/Pyrones; 9007-81-2/Freund's Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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