| Vulpinic acids as potential antiinflammatory agents. 1. Vulpinic acids with substituents in the aromatic rings. | |
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MedLine Citation:
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PMID: 1120988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preparation of a series of vulpinic acids, substituted in either or both of the aromatic rings, is described. The compounds were found to be active in the adjuvant arthritis test in rats. High activity combined with an acceptable therapeutic ratio was confined to analogs with electron-withdrawing substituents in the meta positions of the rings. |
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Authors:
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F R Foden; J McCormick; D M O'Mant |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 18 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-06-20 Completed Date: 1975-06-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / adverse effects, chemical synthesis*, therapeutic use Arthritis, Rheumatoid / drug therapy, immunology Benzylidene Compounds / adverse effects, chemical synthesis, therapeutic use Dose-Response Relationship, Drug Freund's Adjuvant Hyperventilation / chemically induced Pyrans / chemical synthesis* Pyrones / adverse effects, chemical synthesis*, therapeutic use Rats Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Benzylidene Compounds; 0/Pyrans; 0/Pyrones; 9007-81-2/Freund's Adjuvant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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