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Vulnerability to sympathetic stress does not persist in Takotsubo stress cardiomyopathy.
MedLine Citation:
PMID:  25267077     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Our objective was to investigate whether dobutamine stress echocardiography (DSE) could induce abnormal cardiac function in Takotsubo stress cardiomyopathy (TSC) patients in a stable condition after the acute attack.
METHODS AND RESULTS: This study is a case-control study and a sub-study of the Stockholm Myocardial Infarction with Normal Coronaries (SMINC) study. Twenty-two patients with a previous episode of TSC and 22 sex- and age-matched controls were recruited from the SMINC study and investigated with DSE. All TSC patients had a previous normal cardiovascular magnetic resonance investigation. Tissue Doppler imaging - derived time-phases of cardiac cycle were recorded to calculate myocardial performance index (MPI) to assess ventricular function. Compared to controls at rest, TSC patients had a small but significantly higher both left ventricular MPI (LV-MPI, 0.53 vs 0.59, p=0.01) and as a trend in right ventricular MPI (RV-MPI, 0.38 vs 0.47, p=0.08) although during DSE these variables did not differ significantly.
CONCLUSION: In this study we found no difference in standard diastolic parameters between TSC and controls, but a significant higher value in LV-MPI in the TSC group at rest. However, no such difference could be demonstrated during DSE between the groups indicating that vulnerability to sympathetic stimulation does not persist in TSC patients.
Authors:
O Collste; M Alam; M Sundqvist; J Olson; J Wardell; P Tornvall; M Frick
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Journal of cardiac failure     Volume:  -     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-30     Completed Date:  -     Revised Date:  2014-10-1    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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