| Vulnerability for psychopathology in Klinefelter syndrome: Age specific and cognitive specific risk profiles. | |
| | |
MedLine Citation:
|
PMID: 21438924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aim: Studying Klinefelter syndrome (47,XXY) can reveal insights into mechanisms of neurodevelopment. Our aim was to identify factors that influence risk for psychopathology in this syndrome, with a focus on age specific and cognitive specific risk profiles. Methods: 73 subjects with Klinefelter syndrome (25 children, 48 adults) and 93 age-matched controls (53 children, 40 adults) participated in the study. The discrepancy between verbal IQ (VIQ) and performance IQ (PIQ) was assessed using the Wechsler Intelligence Scales. IQ data were only measured in the Klinefelter group. All participants completed the Autism Questionnaire and Schizotypal Personality Questionnaire. Results: Increased levels of autism traits and schizotypal traits were observed in individuals Klinefelter syndrome, with schizotypal traits increasing with age. The VIQ<PIQ group (n=33) showed significantly increased levels of autism traits compared to the PIQ<VIQ group (n=12) and controls. The PIQ<VIQ group showed significantly increased levels of schizotypal traits compared to the VIQ<PIQ group and controls. The VIQ-PIQ discrepancy significantly correlated with schizotypal traits and autism traits, in opposite directions. Conclusion: Risk for psychopathology in Klinefelter syndrome may be age-specific as well as dependent on cognitive profile. Relative deficits in verbal abilities seem more strongly associated with increased autism traits, whereas relative deficits in visuospatial abilities seem more strongly associated with increased schizotypal traits. |
| | |
Authors:
|
Sophie van Rijn; Hanna Swaab |
Related Documents
:
|
21373784 - Joint hypermobility syndrome: problems that require psychological intervention. 18766124 - Hypertrophic osteoarthropathy in the hepatopulmonary syndrome. 11216824 - Biventricular hypertrophic cardiomyopathy with right ventricular outflow tract obstruct... 21121904 - Alterations in white matter pathways in angelman syndrome. 2241394 - Job's syndrome: a rare cause of recurrent lung abscess in childhood. 2501774 - Fetal hydantoin syndrome: a case report. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-25 |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
|
Leiden University, Clinical Child and Adolescent Studies, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Follow-up studies of very low birthweight children in Sweden.
Next Document: Facing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical ...