| Vulnerability genes or plasticity genes? | |
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MedLine Citation:
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PMID: 19455150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to adversity because of their genetic make up as simultaneously most likely to benefit from supportive or enriching experiences-or even just the absence of adversity. Recent G x E findings consistent with this perspective and involving monoamine oxidase-A, 5-HTTLPR (5-hydroxytryptamine-linked polymorphic region polymorphism) and dopamine receptor D4 (DRD4) are reviewed for illustrative purposes. Results considered suggest that putative 'vulnerability genes' or 'risk alleles' might, at times, be more appropriately conceptualized as 'plasticity genes', because they seem to make individuals more susceptible to environmental influences-for better and for worse. |
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Authors:
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J Belsky; C Jonassaint; M Pluess; M Stanton; B Brummett; R Williams |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-05-19 |
Journal Detail:
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Title: Molecular psychiatry Volume: 14 ISSN: 1476-5578 ISO Abbreviation: Mol. Psychiatry Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-23 Completed Date: 2009-11-30 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9607835 Medline TA: Mol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 746-54 Citation Subset: IM |
Affiliation:
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Institute for the Study of Children, Families and Social Issues, Birkbeck University of London, London, UK. j.belsky@bbk.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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genetics Adaptation, Psychological* / physiology Animals Disease Susceptibility* Environment Genetic Predisposition to Disease* Humans Mental Disorders / genetics*, psychology Psychological Theory Stress, Psychological / genetics, physiopathology*, psychology |
| Grant Support | |
ID/Acronym/Agency:
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3P01 HL036587/HL/NHLBI NIH HHS; M01RR301/RR/NCRR NIH HHS; R01AG19605/AG/NIA NIH HHS |
| Comments/Corrections | |
Comment In:
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Mol Psychiatry. 2010 Sep;15(9):881-2
[PMID:
20010890
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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