Document Detail


Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability.
MedLine Citation:
PMID:  21252306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Moderate maternal nutrient restriction during pregnancy occurs in both developing and developed countries. In addition to poverty, maternal dieting, teenage pregnancy, and uterine vascular problems in older mothers are causes of decreased fetal nutrition. We evaluated the impact of global 30% maternal nutrient reduction (MNR) on early fetal baboon brain maturation. MNR induced major cerebral developmental disturbances without fetal growth restriction or marked maternal weight reduction. Mechanisms evaluated included neurotrophic factor suppression, cell proliferation and cell death imbalance, impaired glial maturation and neuronal process formation, down-regulation of gene ontological pathways and related gene products, and up-regulated transcription of cerebral catabolism. Contrary to the known benefits from this degree of dietary reduction on life span, MNR in pregnancy compromises structural fetal cerebral development, potentially having an impact on brain function throughout life.
Authors:
Iwa Antonow-Schlorke; Matthias Schwab; Laura A Cox; Cun Li; Kristina Stuchlik; Otto W Witte; Peter W Nathanielsz; Thomas J McDonald
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-20
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-04-14     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3011-6     Citation Subset:  IM    
Affiliation:
Hans Berger Department of Neurology, Friedrich Schiller University, D-07740 Jena, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology*,  metabolism
Brain-Derived Neurotrophic Factor / metabolism
Cell Death / physiology
Cell Proliferation
Female
Fetus / embryology
Gene Expression Profiling
Gene Expression Regulation / physiology
Image Processing, Computer-Assisted
Immunohistochemistry
Insulin-Like Growth Factor Binding Proteins / metabolism
Insulin-Like Growth Factor I / metabolism
Maternal Nutritional Physiological Phenomena / physiology*
Papio / embryology*
Pregnancy
Receptors, Somatomedin / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
HD21350-17/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Insulin-Like Growth Factor Binding Proteins; 0/Receptors, Somatomedin; 67763-96-6/Insulin-Like Growth Factor I
Comments/Corrections
Comment In:
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2641-2   [PMID:  21297035 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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