Document Detail


Vulgarenol, a sesquiterpene isolated from Magnolia grandiflora, induces nitric oxide synthases II and III overexpression in guinea pig hearts.
MedLine Citation:
PMID:  18069247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vulgarenol, a sesquiterpene isolated from Magnolia grandiflora flower petals, decreased coronary vascular resistance in the Langendorff isolated and perfused heart model, when compared to the control group [(15.2 x 10(7) +/- 1.0 x 10(7)) dyn s cm(-5) vs. (36.8 x 10(7) +/- 1.2 x 10(7)) dyn s cm(-5)]. Our data suggest that this coronary vasodilator effect probably involved inducible and endothelial nitric oxide synthase overexpression (6.8 and 4.2 times over control, respectively), which correlated with increases in nitric oxide release [(223 +/- 9) pmol mL(-1) vs. (61 +/- 11) pmol mL(-1)] and in cyclic guanosine monophosphate production [(142 +/- 8) pmol mg(-1) of tissue vs. (44 +/- 10) pmol mg(-1) of tissue], as compared to control values. This effect was antagonized by 3 microm gadolinium(III) chloride, 100 microM N-nitro-L-arginine methyl ester, and 10 microM 1H-[1,2,4]oxadiazolo[4,2-a]quinoxalin-1-one. Hence, the vulgarenol-elicited coronary vasodilator effect could be mediated by the nitric oxide-soluble guanylyl cyclase pathway.
Authors:
Leonardo del Valle-Mondragón; Fermin Alejandro Tenorio-López; Gabriela Zarco-Olvera; Gustavo Pastelín-Hernández
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  62     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-12-11     Completed Date:  2008-02-21     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Sección XVI, 14080, Tlalpan, DF México. leonardodvm65@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclic GMP / metabolism
Flowers / chemistry
Gene Expression Regulation, Enzymologic / drug effects*
Guinea Pigs
Heart / drug effects
Magnolia / chemistry*
Myocardium / enzymology*
Nitric Oxide / biosynthesis
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type II / genetics*
Nitric Oxide Synthase Type III / genetics*
Sesquiterpenes / isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/3,4,9-trihydroxy-9-methyl-3a,5,5a,9,9a,9b-hexahydronaphtho(1,2-b)furan-2,6(3H,4H)-dione; 0/Sesquiterpenes; 10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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