Document Detail

Vulgarenol, a sesquiterpene isolated from Magnolia grandiflora, induces nitric oxide synthases II and III overexpression in guinea pig hearts.
MedLine Citation:
PMID:  18069247     Owner:  NLM     Status:  MEDLINE    
Vulgarenol, a sesquiterpene isolated from Magnolia grandiflora flower petals, decreased coronary vascular resistance in the Langendorff isolated and perfused heart model, when compared to the control group [(15.2 x 10(7) +/- 1.0 x 10(7)) dyn s cm(-5) vs. (36.8 x 10(7) +/- 1.2 x 10(7)) dyn s cm(-5)]. Our data suggest that this coronary vasodilator effect probably involved inducible and endothelial nitric oxide synthase overexpression (6.8 and 4.2 times over control, respectively), which correlated with increases in nitric oxide release [(223 +/- 9) pmol mL(-1) vs. (61 +/- 11) pmol mL(-1)] and in cyclic guanosine monophosphate production [(142 +/- 8) pmol mg(-1) of tissue vs. (44 +/- 10) pmol mg(-1) of tissue], as compared to control values. This effect was antagonized by 3 microm gadolinium(III) chloride, 100 microM N-nitro-L-arginine methyl ester, and 10 microM 1H-[1,2,4]oxadiazolo[4,2-a]quinoxalin-1-one. Hence, the vulgarenol-elicited coronary vasodilator effect could be mediated by the nitric oxide-soluble guanylyl cyclase pathway.
Leonardo del Valle-Mondragón; Fermin Alejandro Tenorio-López; Gabriela Zarco-Olvera; Gustavo Pastelín-Hernández
Related Documents :
7978477 - Heterogeneous vasomotor responses of rabbit coronary microvessels to isoflurane.
8737047 - Structure-activity relationships of some novel coronary dilator derivatives of palmitoy...
10435027 - Coronary vasoconstriction to endothelin-1 increases with age before and after ischaemia...
3545177 - Left ventricular receptors: physiological controllers or pathological curiosities?
6979467 - Recovery of right ventricular function following repair of acute ventricular septal def...
2812527 - Changes in cardiac neuropeptide y after experimental myocardial infarction in rat.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  62     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-12-11     Completed Date:  2008-02-21     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Sección XVI, 14080, Tlalpan, DF México.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cyclic GMP / metabolism
Flowers / chemistry
Gene Expression Regulation, Enzymologic / drug effects*
Guinea Pigs
Heart / drug effects
Magnolia / chemistry*
Myocardium / enzymology*
Nitric Oxide / biosynthesis
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type II / genetics*
Nitric Oxide Synthase Type III / genetics*
Sesquiterpenes / isolation & purification,  pharmacology*
Reg. No./Substance:
0/3,4,9-trihydroxy-9-methyl-3a,5,5a,9,9a,9b-hexahydronaphtho(1,2-b)furan-2,6(3H,4H)-dione; 0/Sesquiterpenes; 10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC Oxide Synthase; EC Oxide Synthase Type II; EC Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of EDTA on lead transportation and accumulation by Sedum alfredii hance.
Next Document:  Biosynthesis of chlorogenic acids in growing and ripening fruits of Coffea arabica and Coffea caneph...