| Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease. | |
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MedLine Citation:
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PMID: 22094481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls. METHODS: Fifteen patients with AD (mean age 72 ± 6 years, Mini-Mental State Examination score [MMSE] 20 ± 6) and 19 age-matched controls (mean age 68 ± 6 years, MMSE 29 ± 1) underwent structural MRI. Participants were injected with 5 mCi of FDG during pseudocontinuous ASL scan, which was followed by PET scanning. Statistical parametric mapping and regions of interest (ROI) analysis were used to compare the ability of the 2 modalities in distinguishing patients from controls. Similarity between the 2 modalities was further assessed with linear correlation maps of CBF and metabolism to neuropsychological test scores. RESULTS: Good agreement between hypoperfusion and hypometabolism patterns was observed, with overlap primarily in bilateral angular gyri and posterior cingulate. ROI results showed similar scales of functional deficit between patients and controls in both modalities. Both ASL and FDG-PET were able to distinguish neural networks associated with different neuropsychological tests with good overlap between modalities. CONCLUSIONS: Our voxel-wise results indicated that ASL-MRI provides largely overlapping information with FDG-PET. ROI analysis demonstrated that both modalities detected similar degrees of functional deficits in affected areas. Given its ease of acquisition and noninvasiveness, ASL-MRI may be an appealing alternative for AD studies. |
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Authors:
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Y Chen; D A Wolk; J S Reddin; M Korczykowski; P M Martinez; E S Musiek; A B Newberg; P Julin; S E Arnold; J H Greenberg; J A Detre |
Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-16 |
Journal Detail:
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Title: Neurology Volume: 77 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: 2012-01-25 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1977-85 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St., Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / diagnosis*, metabolism Cerebrovascular Circulation / physiology Energy Metabolism / physiology Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Angiography / methods* Male Middle Aged Positron-Emission Tomography / methods* Predictive Value of Tests Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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MH080729/MH/NIMH NIH HHS; NS058386/NS/NINDS NIH HHS; RR002305/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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Nat Rev Neurol. 2012 Jan;8(1):3
[PMID:
22198394
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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