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Voxel-based relaxometry for cases of an unresolved epilepsy diagnosis.
MedLine Citation:
PMID:  22342566     Owner:  NLM     Status:  Publisher    
PURPOSE: Voxel-based relaxometry (VBR) is a technique in which a voxel-level statistical comparison of quantitative MR T2 maps is performed to identify regions with significantly elevated T2 relaxation time. Our objective was to assess the performance of single-subject VBR at 3T as a diagnostic tool for patients whose diagnosis of epilepsy or seizure focus location is uncertain. METHODS: Fifty-nine patients with possible epilepsy or known epilepsy, but an unknown focus and forty-five healthy controls were studied. All subjects were scanned at 3T using a Carr-Purcell-Meiboom-Gill MR sequence. Single-subject VBR was performed at a significance level of α=0.001. Patients were classified based on whether the diagnosis of epilepsy was in question and whether there was a suspected focus. A VBR score was determined based on the presence of VBR abnormalities in any of 13 predefined regions per hemisphere. RESULTS: All patients exhibited significantly more median VBR abnormalities than controls (p<0.05). VBR abnormalities were seen in 69% and 89% of patients with a normal or questionably abnormal MR scan, respectively. Nineteen of the 27 patients with a suspected focus (70%) had VBR abnormalities in the suspected focus, with additional regions of involvement being elucidated. VBR also correctly predicted the seizure focus in 50% of patients whose seizure foci were confirmed based on follow-up history or clinical investigations. CONCLUSIONS: Single subject VBR can help identify potential seizure foci in patients whose seizure foci are uncertain.
Robert K Kosior; Rachel Sharkey; Richard Frayne; Paolo Federico
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Epilepsy research     Volume:  -     ISSN:  1872-6844     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Department of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Calgary, Alberta, Canada.
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