Document Detail

Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy-a comparison between clinical subtypes and correlations with clinical parameters.
MedLine Citation:
PMID:  17512219     Owner:  NLM     Status:  MEDLINE    
Multiple system atrophy (MSA) is a neurodegenerative disease affecting basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord. Clinically, a cerebellar (MSA-C) and a parkinsonian variant of MSA (MSA-P) are distinguished. We used voxel-based morphometry (VBM) and voxel-based relaxometry (VBR) in 48 MSA patients (32 MSA-C, 16 MSA-P) and 46 controls. In MSA-C, VBM revealed gray matter loss in cerebellum, right thalamus, both putamina and several cortical regions including insular cortex. Gray matter loss in the cerebellum and insular cortex was correlated with disease duration and severity. There was white matter loss in the brainstem, which was correlated with disease duration and severity. VBR analysis in MSA-C showed decreased relaxation rate R2 in cerebellum, pontine brainstem and cortical regions including insular cortex. In MSA-P, gray matter was reduced in cerebellum, dorsal midbrain, both putamina, and several cortical regions including insular cortex. A correlation with disease duration and severity was detected only for some small cortical areas. Direct comparison of MSA-C and MSA-P showed differences only in infratentorial brain regions where structural abnormalities were more pronounced in MSA-C than in MSA-P. In MSA-C, there was a stronger reduction of gray matter in the basal parts of the cerebellum, of white matter in the brainstem and of the relaxation rate R2 in the cerebellum and brainstem.
M Minnerop; K Specht; J Ruhlmann; N Schimke; M Abele; A Weyer; U Wüllner; T Klockgether
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Publication Detail:
Type:  Journal Article     Date:  2007-04-25
Journal Detail:
Title:  NeuroImage     Volume:  36     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1086-95     Citation Subset:  IM    
Department of Neurology, University Hospital of Bonn, Bonn, Germany.
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MeSH Terms
Brain / pathology*
Cerebellum / pathology
Cerebral Cortex / pathology
Diagnosis, Differential
Disease Progression
Dominance, Cerebral / physiology
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Middle Aged
Multiple System Atrophy / diagnosis*
Nerve Fibers, Myelinated / pathology
Olivopontocerebellar Atrophies / pathology
Parkinsonian Disorders / diagnosis
Pons / pathology
Putamen / pathology
Sensitivity and Specificity
Statistics as Topic
Thalamus / pathology

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